Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. We aimed to study the incidence of hepatocellular carcinoma (HCC) and cirrhotic complications in psychiatric patients.. ..We included 105,763 psychiatric patients without prior liver-related events in the final… Continue reading High incidence of #hepatocellular carcinoma and #cirrhotic complications in patients with psychiatric illness: a territory-wide cohort study
Category: Hepatology
Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4
Background Alcoholic liver disease (ALD) is a public health concern that is the cause of half of all cirrhosis‐related deaths. Early detection of fibrosis, ideally in the pre‐cirrhotic stage, is a key strategy for improving ALD outcomes and for preventing progression to cirrhosis. Previous studies identified the blood‐borne marker human microfibrillar‐associated protein 4 (MFAP4) as… Continue reading Prediction of liver fibrosis severity in alcoholic liver disease by human microfibrillar‐associated protein 4
Dietary Patterns Are Associated with Likelihood of Hepatic #Steatosis among US Adults
Non‐alcoholic fatty liver disease (NAFLD) is a rapidly growing public health problem. In this study, we explored the association between dietary patterns (DPs) and fatty liver and liver function tests.. ..Of the 20643 eligible participants, 45.7% had prevalent fatty liver. Three DPs collectively explained 50.8% of variance in dietary nutrients consumption. The first DP was… Continue reading Dietary Patterns Are Associated with Likelihood of Hepatic #Steatosis among US Adults
CDC Hepatitis C screening among adults
..CDC is augmenting previous guidance with two new recommendations: 1) hepatitis C screening at least once in a lifetime for all adults aged ≥18 years, except in settings where the prevalence of HCV infection is <0.1% and 2) hepatitis C screening for all pregnant women during each pregnancy, except in settings where the prevalence of… Continue reading CDC Hepatitis C screening among adults
Plant‐based and animal‐based low‐carbohydrate #diets and risk of #hepatocellular carcinoma among US men and women
Little is known about the role of low‐carbohydrate diets (LCDs) in the development of hepatocellular carcinoma (HCC).. ..During 3,664,769 person years of follow‐up, there were 156 incident HCC cases. Although there were no associations between overall or animal‐based LCD score and risk of HCC, plant‐based LCD score was inversely associated with HCC risk (HR: 0.83;… Continue reading Plant‐based and animal‐based low‐carbohydrate #diets and risk of #hepatocellular carcinoma among US men and women
Ethnic influence on #nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016
Amongst the study population of 4538 persons, NAFLD prevalence was 32.5%, lowest in non‐Hispanic Blacks (18.0%) and Asians (18.1%), highest amongst Mexican Americans (48.4%). Within the NAFLD group, advanced fibrosis was highest in non‐Hispanic Blacks (28.5%) and lowest amongst non‐Hispanic Asians (2.7%). Of the 1473 (97.5%) NAFLD participants who answered NAFLD awareness question, 90% visited… Continue reading Ethnic influence on #nonalcoholic fatty liver disease prevalence and lack of disease awareness in the United States, 2011–2016
Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise
We have shown that combination treatment with decaffeinated green tea extract (GTE) and voluntary exercise (Ex) reduces obesity and insulin resistance in high-fat (HF)-fed mice to a greater extent than either treatment alone. Here, we investigated the effects of GTE-, Ex- or the combination on the development of obesity-related NAFLD.. ..Combination treated, but not singly… Continue reading Mitigation of nonalcoholic #fatty liver disease in high-fat-fed mice by the combination of decaffeinated green tea extract and voluntary exercise
Unresolved issues of immune tolerance in chronic hepatitis #B
During the natural course of chronic hepatitis B virus infection, immune-tolerant phase is characterized by high viral replication, the presence of HBV e antigen (HBeAg), and normal or minimally elevated serum alanine aminotransferase. Immune-tolerant phase is usually regarded as a benign course of the disease. International guidelines recommend observation rather than treatment during immune-tolerant phase.… Continue reading Unresolved issues of immune tolerance in chronic hepatitis #B
#Obesity Is the Most Common Risk Factor for Chronic #liver Disease
Obesity has been associated with liver fibrosis, yet guidelines do not emphasize it as an independent risk factor in which to have a high index of suspicion of advanced disease.. ..We prospectively recruited patients from a primary care practice with hazardous alcohol use and/or type 2 diabetes and/or obesity. Subjects were invited for a transient… Continue reading #Obesity Is the Most Common Risk Factor for Chronic #liver Disease
2 Medical News 