Refractory hepatic encephalopathy (HE) is a complex and debilitating disorder that significantly impacts healthcare utilization and causes lingering cognitive defects that can at times be permanent. It represents an economically and emotionally costly entity for patients and caregivers. Precipitants and pathogenic factors of this disease are numerous, cumulative, and often present with subtle features. A… Continue reading ReviewManagement of Refractory #Hepatic #Encephalopathy
Category: Hepatology
Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
Aim: In this cohort, we aimed to study the evolution of pregenomic RNA (pgRNA) during treatment and compare it with other disease scores such as FIB-4 and PAGE-B.Methods: Eighty-eight HBeAg negative CHB who received long-term treatment with NAs were included. A quantitative HBV S antigen (HBsAg) assay was performed, and viral HBV DNA was quantified… Continue reading Is there any role for #HBV pgRNA in #fibrosis and #HCC predisposition?
#Statins and clinical outcomes in patients with advanced #hepatocellular carcinoma treated with #Atezolizumab plus #Bevacizumab
The impact of statins on patients receiving immune checkpoint inhibitors for advanced hepatocellular carcinoma (aHCC) remains unclear. This study aimed to evaluate whether statins influence overall survival (OS) and progression-free survival (PFS) in aHCC patients receiving Atezolizumab + Bevacizumab (A + B). ARTE is a prospectively maintained dataset of 305 aHCC patients treated with A… Continue reading #Statins and clinical outcomes in patients with advanced #hepatocellular carcinoma treated with #Atezolizumab plus #Bevacizumab
#Tetrachloroethylene Is Associated With Presence of Significant Liver #Fibrosis: A National Cross-Sectional Study in US Adults
Background & AimsTetrachloroethylene (PCE) is a volatile organic compound (VOC) used in industrial settings. Pre-clinical studies have linked PCE to hepatotoxicity, but clinical data beyond selected occupational cohorts represent a critical knowledge gap.MethodsWe utilised data from the National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020, a nationally representative survey of the US… Continue reading #Tetrachloroethylene Is Associated With Presence of Significant Liver #Fibrosis: A National Cross-Sectional Study in US Adults
#Artificial #Intelligence and #Machine #Learning Applications in #Liver Disease
AbstractArtificial intelligence and machine learning are transforming hepatology by integrating clinical, laboratory, imaging, and wearable data for earlier diagnosis, risk prediction, and patient management. These technologies enable personalized care and noninvasive monitoring across metabolic dysfunction-associated steatotic liver disease, cirrhosis, hepatitis C, liver transplantation, and hepatocellular carcinoma. Ongoing advances in digital health and interpretability will enhance… Continue reading #Artificial #Intelligence and #Machine #Learning Applications in #Liver Disease
#Coffee for the #liver: a mechanistic approach
The liver, which is essential for metabolism and detoxification, is vulnerable to various damaging factors, including viral infections, excessive alcohol consumption, and a diet high in fat and sugar. Coffee, one of the most widely consumed beverages worldwide, is valued not only for its flavor and aroma but also for its potential health benefits. In… Continue reading #Coffee for the #liver: a mechanistic approach
Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
This study aimed to investigate the association between dietary vitamin K intake and all-cause mortality in individuals with non-alcoholic fatty liver disease (NAFLD). We analyzed data from 7857 NAFLD participants in the National Health and Nutrition Examination Survey (NHANES 2005–2018) linked to mortality outcomes from the National Death Index (NDI). Dietary vitamin K intake was… Continue reading Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
BackgroundTransarterial chemoembolisation (TACE) is standard care for unresectable, non-metastatic hepatocellular carcinoma. We aimed to evaluate the addition of lenvatinib and pembrolizumab to TACE versus dual placebo plus TACE in patients with unresectable, non-metastatic hepatocellular carcinoma.MethodsIn this multicentre, randomised, double-blind, phase 3 study (LEAP-012), patients were recruited from 137 global sites in 33 countries or regions.… Continue reading Transarterial #chemoembolisation combined with lenvatinib plus pembrolizumab versus dual placebo for unresectable, non-metastatic #hepatocellular carcinoma (LEAP-012): a multicentre, randomised, double-blind, phase 3 study
Stereotactic Body Radiotherapy vs #Sorafenib Alone in #Hepatocellular Carcinoma
Question Does stereotactic body radiation therapy (SBRT) prior to systemic therapy improve overall survival compared with systemic therapy alone in patients with locally advanced hepatocellular carcinoma (HCC)?Findings This phase 3 randomized clinical trial found that the use of SBRT prior to sorafenib was associated with clinically important but not statistically significant improved overall survival in… Continue reading Stereotactic Body Radiotherapy vs #Sorafenib Alone in #Hepatocellular Carcinoma
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