Background: REBYOTA and VOWST are the first FDA-approved live biotherapeutic products (LBPs) for recurrent Clostridioides difficile infection (rCDI). Prior FDA safety alerts (2019-2020) regarding invasive infections from investigational fecal microbiota transplantation underscore the need for post-marketing surveillance of these novel products.Aims: To characterize the real-world safety profiles of REBYOTA and VOWST using the FDA Adverse… Continue reading Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Category: Gastroenterology
The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease
This document outlines an updated guideline from the British Society of Gastroenterology, detailing the standards for diagnosing and managing adult coeliac disease (CD). A multidisciplinary panel from across the UK, Sweden, Italy and Australia contributed to the development of these guidelines. This update is prompted by recent advancements in the diagnosis and treatment of adult… Continue reading The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease
Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Background and aims: Esophageal varices (EV) are a major complication of portal hypertension in decompensated chronic liver disease (DCLD), but endoscopy is invasive and resource-limited. This study assessed serum-ascites albumin gradient (SAAG) as a noninvasive predictor of EV occurrence and severity.Patients and methods: Prospective cross-sectional study (January 2023-May 2024) of 76 adults (≥18 years) with… Continue reading Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Background: Ivermectin suppresses tumor growth in various cancers. However, the mechanism of action in cancer remains unclear. This study aimed to investigate the anticancer activity of ivermectin against gastric cancer cell lines and patient-derived organoids.Methods: Cell viability was measured in SNU719 and SNU620 gastric cancer cell lines. Protein expression levels of apoptosis-related markers were analyzed… Continue reading Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Severe Malnutrition in a Young Adult: Diagnostic Challenges in a Multifactorial Case With Helicobacter pylori Infection
Severe malnutrition in adults is frequently multifactorial and may result from overlapping nutritional, infectious, inflammatory, and systemic conditions. Identifying the dominant contributors can be challenging, particularly when patients present without classic gastrointestinal symptoms. We report the case of a 24-year-old woman with a more than 10-year history of failure to gain weight despite adequate nutritional… Continue reading Severe Malnutrition in a Young Adult: Diagnostic Challenges in a Multifactorial Case With Helicobacter pylori Infection
Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) represent a high-risk population with competing comorbidities, complex medication regimens, and overlapping inflammatory pathways. Although the role of sodium-glucose co-transporter-2 (SGLT2) inhibitors in managing type 2 diabetes is well-established, their impact on outcomes in diabetic patients with coexisting IBD remains unclear. This study aimed to investigate the… Continue reading Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
Synergistic anti-Helicobacter pylori efficacy of a molecularly identified Limosilactobacillus fermentum isolate in combination with multiple antibiotics
Background: Helicobacter pylori (H. pylori) is a Gram-negative gastric pathogen resistant to the acidic stomach environment through urease-mediated neutralization, enabling colonization of the gastric mucosa. It is a major cause of gastritis, peptic ulcer disease, and gastric cancer, and was classified as a Class I carcinogen by the International Agency for Research on Cancer (IARC)… Continue reading Synergistic anti-Helicobacter pylori efficacy of a molecularly identified Limosilactobacillus fermentum isolate in combination with multiple antibiotics
Elobixibat Versus Prucalopride in Functional Constipation: A Prospective Comparative Effectiveness Study
Background and aims: The choice of second-line therapy in functional constipation (FC) is often empirical, owing to the lack of direct comparisons between agents with distinct mechanisms of action. Elobixibat, an ileal bile acid transporter inhibitor, and prucalopride, a selective 5-HT4 receptor agonist, represent two different therapeutic approaches targeting intestinal secretion and colonic motility. This… Continue reading Elobixibat Versus Prucalopride in Functional Constipation: A Prospective Comparative Effectiveness Study
High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
Background/aims: #Pancreatic exocrine insufficiency (PEI) is a condition characterized by impaired digestion and absorption resulting from insufficient exocrine secretion of the pancreas. The current study aimed to determine the prevalence, clinical characteristics, and associated risk factors of PEI in patients presenting to the gastroenterology outpatient clinic with common gastrointestinal complaints such as abdominal pain, dyspepsia,… Continue reading High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
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