Artificial intelligence (AI) has emerged as a transformative tool in gastrointestinal (GI) endoscopy, addressing challenges in detection, diagnosis, and decision-making. In upper GI endoscopy, AI supports blind spot monitoring, Helicobacter pylori diagnosis, and the identification of premalignant and malignant lesions, with high accuracy and reduced miss rates. In lower GI endoscopy, computer-aided detection improves adenoma… Continue reading Translating artificial intelligence into clinical practice for gastrointestinal endoscopy: current applications and future perspectives
Category: Gastroenterology
Association Between Helicobacter pylori Infection and Iron Deficiency Anemia in Adult Patients Attending a Tertiary Care Hospital
Background: Iron deficiency anemia (IDA) has been increasingly associated with Helicobacter pylori (H. pylori) infection, especially in developing countries.Objective: This study aimed to evaluate the association between H. pylori infection and IDA severity and to compare hematological parameters between H. pylori-positive and -negative adult patients attending a tertiary care hospital.Methodology: This was a cross-sectional analytical… Continue reading Association Between Helicobacter pylori Infection and Iron Deficiency Anemia in Adult Patients Attending a Tertiary Care Hospital
Colorectal cancer incidence and mortality by age group, colon location, and histology in Canada
Background: Colorectal cancer (CRC) incidence is increasing among younger individuals in many countries. We examined CRC incidence and mortality by age group, site, and histology in Canada.Methods: Data from the Canadian Cancer Registry and the Canadian Vital Statistics Death Database were used to determine CRC incidence from 1992 to 2019 and mortality from 1974 to… Continue reading Colorectal cancer incidence and mortality by age group, colon location, and histology in Canada
Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
Background: REBYOTA and VOWST are the first FDA-approved live biotherapeutic products (LBPs) for recurrent Clostridioides difficile infection (rCDI). Prior FDA safety alerts (2019-2020) regarding invasive infections from investigational fecal microbiota transplantation underscore the need for post-marketing surveillance of these novel products.Aims: To characterize the real-world safety profiles of REBYOTA and VOWST using the FDA Adverse… Continue reading Post-Marketing Safety Signals of Microbiota-Based Live Biotherapeutic Products for Recurrent Clostridioides difficile Infection: A FAERS Pharmacovigilance Study
The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease
This document outlines an updated guideline from the British Society of Gastroenterology, detailing the standards for diagnosing and managing adult coeliac disease (CD). A multidisciplinary panel from across the UK, Sweden, Italy and Australia contributed to the development of these guidelines. This update is prompted by recent advancements in the diagnosis and treatment of adult… Continue reading The 2026 British Society of Gastroenterology guidelines on the diagnosis and management of adult coeliac disease
Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Background and aims: Esophageal varices (EV) are a major complication of portal hypertension in decompensated chronic liver disease (DCLD), but endoscopy is invasive and resource-limited. This study assessed serum-ascites albumin gradient (SAAG) as a noninvasive predictor of EV occurrence and severity.Patients and methods: Prospective cross-sectional study (January 2023-May 2024) of 76 adults (≥18 years) with… Continue reading Correlation of Serum-ascites Albumin Gradient with Occurrence and Severity of Esophageal Varices in Decompensated Chronic Liver Disease: An Observational Study
Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Background: Ivermectin suppresses tumor growth in various cancers. However, the mechanism of action in cancer remains unclear. This study aimed to investigate the anticancer activity of ivermectin against gastric cancer cell lines and patient-derived organoids.Methods: Cell viability was measured in SNU719 and SNU620 gastric cancer cell lines. Protein expression levels of apoptosis-related markers were analyzed… Continue reading Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Severe Malnutrition in a Young Adult: Diagnostic Challenges in a Multifactorial Case With Helicobacter pylori Infection
Severe malnutrition in adults is frequently multifactorial and may result from overlapping nutritional, infectious, inflammatory, and systemic conditions. Identifying the dominant contributors can be challenging, particularly when patients present without classic gastrointestinal symptoms. We report the case of a 24-year-old woman with a more than 10-year history of failure to gain weight despite adequate nutritional… Continue reading Severe Malnutrition in a Young Adult: Diagnostic Challenges in a Multifactorial Case With Helicobacter pylori Infection
Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) represent a high-risk population with competing comorbidities, complex medication regimens, and overlapping inflammatory pathways. Although the role of sodium-glucose co-transporter-2 (SGLT2) inhibitors in managing type 2 diabetes is well-established, their impact on outcomes in diabetic patients with coexisting IBD remains unclear. This study aimed to investigate the… Continue reading Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
