Background: Ivermectin suppresses tumor growth in various cancers. However, the mechanism of action in cancer remains unclear. This study aimed to investigate the anticancer activity of ivermectin against gastric cancer cell lines and patient-derived organoids.Methods: Cell viability was measured in SNU719 and SNU620 gastric cancer cell lines. Protein expression levels of apoptosis-related markers were analyzed… Continue reading Tumor growth suppression of ivermectin in gastric cancer cell lines and primary gastric cancer organoids
Category: Gastroenterology
Severe Malnutrition in a Young Adult: Diagnostic Challenges in a Multifactorial Case With Helicobacter pylori Infection
Severe malnutrition in adults is frequently multifactorial and may result from overlapping nutritional, infectious, inflammatory, and systemic conditions. Identifying the dominant contributors can be challenging, particularly when patients present without classic gastrointestinal symptoms. We report the case of a 24-year-old woman with a more than 10-year history of failure to gain weight despite adequate nutritional… Continue reading Severe Malnutrition in a Young Adult: Diagnostic Challenges in a Multifactorial Case With Helicobacter pylori Infection
Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
diabetes mellitus (T2DM) and inflammatory bowel disease (IBD) represent a high-risk population with competing comorbidities, complex medication regimens, and overlapping inflammatory pathways. Although the role of sodium-glucose co-transporter-2 (SGLT2) inhibitors in managing type 2 diabetes is well-established, their impact on outcomes in diabetic patients with coexisting IBD remains unclear. This study aimed to investigate the… Continue reading Hospitalization, ICU admission, and mortality among diabetic patients with inflammatory bowel disease receiving SGLT-2 inhibitors: a retrospective cohort study from the global collaborative network
Synergistic anti-Helicobacter pylori efficacy of a molecularly identified Limosilactobacillus fermentum isolate in combination with multiple antibiotics
Background: Helicobacter pylori (H. pylori) is a Gram-negative gastric pathogen resistant to the acidic stomach environment through urease-mediated neutralization, enabling colonization of the gastric mucosa. It is a major cause of gastritis, peptic ulcer disease, and gastric cancer, and was classified as a Class I carcinogen by the International Agency for Research on Cancer (IARC)… Continue reading Synergistic anti-Helicobacter pylori efficacy of a molecularly identified Limosilactobacillus fermentum isolate in combination with multiple antibiotics
Elobixibat Versus Prucalopride in Functional Constipation: A Prospective Comparative Effectiveness Study
Background and aims: The choice of second-line therapy in functional constipation (FC) is often empirical, owing to the lack of direct comparisons between agents with distinct mechanisms of action. Elobixibat, an ileal bile acid transporter inhibitor, and prucalopride, a selective 5-HT4 receptor agonist, represent two different therapeutic approaches targeting intestinal secretion and colonic motility. This… Continue reading Elobixibat Versus Prucalopride in Functional Constipation: A Prospective Comparative Effectiveness Study
High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
Background/aims: #Pancreatic exocrine insufficiency (PEI) is a condition characterized by impaired digestion and absorption resulting from insufficient exocrine secretion of the pancreas. The current study aimed to determine the prevalence, clinical characteristics, and associated risk factors of PEI in patients presenting to the gastroenterology outpatient clinic with common gastrointestinal complaints such as abdominal pain, dyspepsia,… Continue reading High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency
Dietary index for gut microbiota (DI-GM) and irritable bowel syndrome: a case-control study
This study investigated whether the Dietary Index for Gut #Microbiota (DI-GM), a measure of diet quality for gut health, is associated with #IBS risk, and symptom severity, inflammation. A case-control study included 350 adults (175 IBS patients per Rome IV and 175 matched controls). Dietary intake was assessed using a validated food frequency questionnaire to… Continue reading Dietary index for gut microbiota (DI-GM) and irritable bowel syndrome: a case-control study
Socioeconomic disparities in biologic persistence among patients with inflammatory bowel disease are associated with increased health care utilization
Introduction: Biologic persistence, defined as the total uninterrupted time on a biologic agent, is associated with improved outcomes in inflammatory bowel disease (#IBD ). However, social determinants of health (SDOH), such as socioeconomic status, may influence a patient's ability to access these medications. We aimed to better understand the relationship between socioeconomic status and biologic… Continue reading Socioeconomic disparities in biologic persistence among patients with inflammatory bowel disease are associated with increased health care utilization
Antibiotic Exposure Patterns and Clinical Outcomes Preceding Clostridioides difficile Infection: A Retrospective Observational Study
Background #Clostridioides difficile infection (CDI) remains a major cause of healthcare-associated morbidity and mortality, with antibiotic exposure recognized as the principal modifiable risk factor. Variability in antibiotic class, duration, and overlap may influence CDI risk and clinical severity. Local audits of prescribing patterns are essential to inform antimicrobial stewardship strategies. Objective The objective of the… Continue reading Antibiotic Exposure Patterns and Clinical Outcomes Preceding Clostridioides difficile Infection: A Retrospective Observational Study
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