Asthma is a heterogeneous disease characterized by chronic airway inflammation and reversible airflow obstruction. Particularly in severe #asthma , airway #mucus plugs can contribute to substantial and persistent airflow obstruction, despite inhaled corticosteroid and bronchodilator treatment. Consequently, it is important that clinicians assess and treat mucus plugs. Increased mucus production and airway eosinophilia caused by… Continue reading Effectiveness of biologics for reducing occlusive mucus plugs in patients with severe asthma: a systematic review
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Microvascular dysfunction in Takotsubo syndrome: a systematic review
Background: Microvascular dysfunction (MD) is advocated as one of the main pathogenic mechanisms of #Takotsubo syndrome (TTS). Several studies investigated MD in TTS using different techniques; however, no systematic review of these data is currently available.Methods: We searched the main scientific database (Embase, Medline, Scopus, PubMed) for articles written in English language using the following… Continue reading Microvascular dysfunction in Takotsubo syndrome: a systematic review
Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease ( #IBD ) is a multisystem illness with intestinal and extraintestinal manifestations. We aimed to analyze the association of developing #pulmonary diseases (PDs) in patients with IBD.Methods: In this retrospective cohort study, TriNetX was used to identify patients with IBD who were prescribed at least one IBD-specific medication or advanced therapy. Patients… Continue reading Increased Prevalence of Pulmonary Diseases in Patients With Inflammatory Bowel Disease
Psychiatry is not the science of unhappiness
#Psychiatry risks losing its conceptual boundaries as the scope of its concern expands to include all forms of human unhappiness. This editorial argues that the discipline must distinguish clearly between illness and adversity, recognising that not all suffering is pathological. Drawing on historical and contemporary debates - from Jaspers' foundational dualism to Engel's biopsychosocial model,… Continue reading Psychiatry is not the science of unhappiness
Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Background: Atezolizumab plus bevacizumab (atezo+bev) is a standard-of-care 1L treatment for unresectable hepatocellular carcinoma (uHCC). Understanding its adoption and use, clinical outcomes, and subsequent therapies are needed.Methods: This retrospective cohort study included 550 patients with u #HCC in the US who initiated 1L atezo+bev between June 2020 and April 2023. Medical records were abstracted to… Continue reading Characteristics and outcomes of patients with #HCC treated with atezolizumab/bevacizumab, stratified by second line therapy
Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice
Background: #Anxiety disorders-including generalized anxiety disorder, posttraumatic stress disorder, and social anxiety disorder-are highly prevalent psychiatric conditions that impose substantial clinical and social burdens. Preclinical and clinical studies have shown that #electroacupuncture (EA) can effectively alleviate anxiety-like behaviors; however, the specific neural circuits and molecular mechanisms underlying EA's therapeutic effects remain incompletely elucidated.Methods: We first… Continue reading Electroacupuncture to point Baihui confers anxiolytic effects by promoting oxytocin release from PVN in Mice
Laparoscopic peritoneal lavage versus surgical resection for the treatment of complicated perforated diverticulitis: A systematic review and meta-analysis
Introduction: Colonic diverticular disease ( #diverticulosis ) is a currently worldwide increasing gastrointestinal disorder with a particularly high prevalence in Western countries. The operative treatment of acute diverticulitis could be executed through open or laparoscopic techniques. A non-resectional procedure, namely laparoscopic peritoneal lavage (LPL) and drainage, has also been adopted as a less invasive treatment… Continue reading Laparoscopic peritoneal lavage versus surgical resection for the treatment of complicated perforated diverticulitis: A systematic review and meta-analysis
Effective prompt design for large language models in clinical #practice
Large language models ( #LLMs ) have emerged as transformative healthcare tools for clinical documentation, diagnostic reasoning, and medical education. However, effective utilization requires understanding prompt engineering principles—the strategic design of inputs to optimize performance while mitigating hallucination, bias, and outdated information.MethodsThis narrative review synthesizes evidence from a structured PubMed search through December 2025 using… Continue reading Effective prompt design for large language models in clinical #practice
Effect of #statin use on prognostic outcomes in #hepatocellular carcinoma following #liver surgery: a systematic review and meta-analysis
Hepatocellular carcinoma (HCC) recurrence remains a significant clinical challenge, even among patients who undergo surgical treatment. Although statins exhibit anticancer properties through several biologically plausible mechanisms, robust clinical evidence supporting their role in preventing HCC recurrence is still limited. This meta-analysis aimed to evaluate the impact of statin use on the prognostic outcomes of patients… Continue reading Effect of #statin use on prognostic outcomes in #hepatocellular carcinoma following #liver surgery: a systematic review and meta-analysis
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