Biologic therapies have emerged as effective treatments for chronic spontaneous #urticaria (CSU), a debilitating skin disease. However, real-world data on their use are limited. This retrospective descriptive study analyzes the time from diagnosis to biologic therapy initiation and the CSU-specific healthcare resource utilization (HCRU) among patients with ≥ 2 urticaria diagnoses or one urticaria and… Continue reading Healthcare Resource Utilization and Use of Biologics in Chronic Spontaneous Urticaria
Category: Dermatology
Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond
Chronic spontaneous #urticaria (CSU) is associated with a substantial disease burden due to its prolonged course and significant impairment of quality of life. The diagnostic process for #CSU involves confirming the diagnosis itself and identifying disease phenotypes or endotypes, cofactors, and comorbid conditions, which may affect disease activity and severity. Immunoglobulin E (IgE) and non-IgE-mediated… Continue reading Immunological Basis of Chronic Spontaneous Urticaria: Immunoglobulin E and Beyond
Dupilumab in Patients With Chronic Spontaneous Urticaria: Phase 3 LIBERTY-CSU CUPID Randomized Clinical Trials
Importance: Chronic spontaneous #urticaria (CSU) is an inflammatory disease characterized by recurrent pruritic hives and/or #angioedema. Many patients with CSU remain symptomatic despite standard-of-care, histamine 1-receptor antagonist (H1-AH) treatment. Dupilumab blocks IL-4/IL-13 signaling and is approved in multiple disease states associated with type 2 inflammation. In the phase 3 LIBERTY-CSU CUPID-A trial, dupilumab significantly reduced… Continue reading Dupilumab in Patients With Chronic Spontaneous Urticaria: Phase 3 LIBERTY-CSU CUPID Randomized Clinical Trials
The Impact of #Probiotics on #Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials
Acne vulgaris is a multifactorial inflammatory skin disorder influenced by hormonal activity, microbial imbalance, and immune dysregulation. While conventional treatments such as antibiotics and retinoids remain effective, their long-term use is often limited by side effects, resistance, and poor adherence. This meta-analysis evaluated the efficacy of probiotics as an adjunct or alternative therapy for acne… Continue reading The Impact of #Probiotics on #Acne Vulgaris: A Meta-Analysis of Randomized Controlled Trials
#Nicotinamide for #Skin #Cancer Chemoprevention
Importance Nicotinamide supplementation has been studied as a chemopreventive medication for reducing skin cancer risk, but large-scale data are limited.Objective To determine the clinical efficacy of nicotinamide supplementation for skin cancer prevention in the general population and among solid organ transplant recipients.Design, Setting, and Participants A retrospective cohort study was conducted using electronic health record… Continue reading #Nicotinamide for #Skin #Cancer Chemoprevention
Preventing #pressure #ulcers by increasing pressure: An unorthodox alternating-pressure mattress
Despite the devastating effects of pressure ulcers (PUs), little is understood about how they can be prevented using alternating-pressure (AP) mattresses. Such mattresses typically aim to minimize the pressures imparted while alternating between different states of pressure to prevent areas of tissue from being persistently occluded of blood flow. In this work, we built an… Continue reading Preventing #pressure #ulcers by increasing pressure: An unorthodox alternating-pressure mattress
Integrative analysis reveals therapeutic potential of #pyrvinium pamoate in #Merkel cell carcinoma
Merkel Cell Carcinoma (MCC) is an aggressive neuroendocrine cutaneous malignancy arising from either ultraviolet-induced mutagenesis or Merkel cell polyomavirus (MCPyV) integration. Despite extensive research, our understanding of the molecular mechanisms driving the transition from normal cells to MCC remains limited. To address this knowledge gap, we assessed the impact of inducible MCPyV T antigens on… Continue reading Integrative analysis reveals therapeutic potential of #pyrvinium pamoate in #Merkel cell carcinoma
#Skin damage signals mediate #allergic sensitization to spatially unlinked antigen
Our current understanding of immunity to pathogens suggests that anatomic coupling of antigens with danger signals is a required feature for the formation of immune memory. However, in the context of pathogen-independent inflammation, the stringency of this anatomical coupling is unclear. Here, we demonstrate that multiple modes of skin injury were sufficient to induce a… Continue reading #Skin damage signals mediate #allergic sensitization to spatially unlinked antigen
#Tattoos as a risk factor for malignant #lymphoma: a population-based case–control study
BackgroundThe popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed but the long-term… Continue reading #Tattoos as a risk factor for malignant #lymphoma: a population-based case–control study
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