Background and ObjectivesConsumption of low- and no-calorie sweeteners (LNCSs) has been associated with adverse health outcomes. However, little is known about the association between consumption of LNCSs and cognition. The aim of this study was to investigate the association between consumption of LNCSs and cognitive decline.MethodsWe conducted a longitudinal observational study using data from civil… Continue reading Association Between Consumption of Low- and No-Calorie Artificial #Sweeteners and #Cognitive DeclineAn 8-Year Prospective Study
Tag: sweeteners
Non-caloric #sweetener effects on brain appetite regulation in individuals across varying body #weights
Sucralose, a widely used non-caloric sweetener, provides sweet taste without calories. Some studies suggest that non-caloric sweeteners stimulate appetite, possibly owing to the delivery of a sweet taste without the post-ingestive metabolic signals that normally communicate with the hypothalamus to suppress hunger. In a randomized crossover trial (ClinicalTrials.gov identifier: NCT02945475), 75 young adults (healthy weight,… Continue reading Non-caloric #sweetener effects on brain appetite regulation in individuals across varying body #weights
#Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
Highlights•Aspartame increases insulin levels through parasympathetic activation•An insulin-dependent mechanism of the aspartame-aggravated atherosclerosis•The CX3CL1-CX3CR1 signaling mediates insulin-induced endothelial inflammation•A CX3CL1-CX3CR1-dependent mechanism of aspartame-exacerbated atherosclerosis SummaryConsumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown. Here, we… Continue reading #Sweetener #aspartame aggravates #atherosclerosis through insulin-triggered inflammation
The artificial sweetener erythritol and cardiovascular event risk
Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200), circulating levels of multiple polyol sweeteners, especially erythritol,… Continue reading The artificial sweetener erythritol and cardiovascular event risk
Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort
Objectives To study the associations between artificial sweeteners from all dietary sources (beverages, but also table top sweeteners, dairy products, etc), overall and by molecule (aspartame, acesulfame potassium, and sucralose), and risk of cardiovascular diseases (overall, coronary heart disease, and cerebrovascular disease).Design Population based prospective cohort study (2009-21).Setting France, primary prevention research.Participants 103 388 participants of the web based NutriNet-Santé… Continue reading Artificial sweeteners and risk of cardiovascular diseases: results from the prospective NutriNet-Santé cohort
Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies
Objective To assess the association between intake of non-sugar sweeteners (NSS) and important health outcomes in generally healthy or overweight/obese adults and children. Design Systematic review following standard Cochrane review methodology. Data sources Medline (Ovid), Embase, Cochrane CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov, and reference lists of relevant publications. Eligibility criteria for selecting… Continue reading Association between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
AbstractNon-caloric artificial sweeteners (NAS) are among the most widely used food additives worldwide, regularly consumed by lean and obese individuals alike. NAS consumption is considered safe and beneficial owing to their low caloric content, yet supporting scientific data remain sparse and controversial. Here we demonstrate that consumption of commonly used NAS formulations drives the development… Continue reading Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles
Replacing nutritive sweetener with non-nutritive sweeteners (NNS) has the potential to improve glycaemic control. The objective of this study was to investigate the effects of consuming artificial NNS (that is, aspartame), natural NNS (that is, monk fruit and stevia), and sucrose-sweetened beverages on 24-h glucose profiles. Ten healthy males took part in this randomised, crossover… Continue reading Effects of non-nutritive (artificial vs natural) sweeteners on 24-h glucose profiles
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