Metal ions present in cellular microenvironment have been implicated as drivers of aggregation of amyloid forming proteins. Zinc (Zn2+) ions have been reported to directly interact with α-synuclein (AS), a causative agent of Parkinson's disease and other neurodegenerative diseases, and promote its aggregation. AS is a small intrinsically disordered protein (IDP) i.e., understanding molecular factors… Continue reading Zinc ions prevent α-synuclein aggregation by enhancing chaperone function of human serum albumin
Tag: Parkinson
Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
BackgroundParkinson's disease (PD) is associated with alterations to the phenomenology of dreaming - including an increased frequency of distressing dreams. Whether distressing dreams may precede the development of PD is unknown. This study investigated the association between frequent distressing dreams and the risk of incident PD.Methods3818 men aged 67 years or older from the Osteoporotic… Continue reading Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
Importance Early features of Parkinson disease (PD) have been described through population-based studies that overrepresent White, affluent groups and may not be generalizable. Objective To investigate the association between risk factors and prediagnostic presentations of PD in an ethnically diverse UK population with high socioeconomic deprivation but universal access to health care. Design, Setting, and… Continue reading Assessment of Risk Factors and Early Presentations of Parkinson Disease in Primary Care in a Diverse UK Population
Intake of Flavonoids and Flavonoid-Rich Foods, and Mortality Risk Among Individuals With Parkinson Disease: A Prospective Cohort Study
AbstractBackground and objectives: Although flavonoids have the potential to exert neuroprotective benefits, evidence of their role in improving survival rates among individuals with Parkinson disease (PD) remains lacking. We aimed to prospectively study the association between pre- and post-diagnosis flavonoid intakes and risk of mortality among individuals with PD identified from two large ongoing cohorts… Continue reading Intake of Flavonoids and Flavonoid-Rich Foods, and Mortality Risk Among Individuals With Parkinson Disease: A Prospective Cohort Study
Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
Randomized clinical trials have shown that aerobic exercise attenuates motor symptom progression in Parkinson's disease, but the underlying neural mechanisms are unclear. Here, we investigated how aerobic exercise influences disease-related functional and structural changes in the cortico-striatal sensorimotor network, which is involved in the emergence of motor deficits in Parkinson's disease. Additionally, we explored effects… Continue reading Aerobic exercise alters brain function and structure in Parkinson’s disease a randomized controlled trial
#Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory #Dance Learning over 3-Years: A Preliminary Longitudinal Investigation
Parkinson’s disease (PD) is a neurodegenerative disease that has a fast progression of motor dysfunction within the first 5 years of diagnosis, showing an annual motor rate of decline of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) between 5.2 and 8.9 points. We aimed to determine both motor and non-motor PD symptom… Continue reading #Parkinson’s Disease Motor Symptom Progression Slowed with Multisensory #Dance Learning over 3-Years: A Preliminary Longitudinal Investigation
A multicentre validation study of the diagnostic value of plasma #neurofilament light
Increased cerebrospinal fluid neurofilament light (NfL) is a recognized biomarker for neurodegeneration that can also be assessed in blood. Here, we investigate plasma NfL as a marker of neurodegeneration in 13 neurodegenerative disorders, Down syndrome, depression and cognitively unimpaired controls from two multicenter cohorts: King’s College London (n = 805) and the Swedish BioFINDER study (n = 1,464). Plasma… Continue reading A multicentre validation study of the diagnostic value of plasma #neurofilament light
#Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis
Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD). ObjectivesTo examine the association between neuroticism and risk of PD in a large cohort and a meta‐analysis of prospective cohort studies. MethodsParticipants from the UK Biobank (N = 490,755) completed a neuroticism scale in… Continue reading #Neuroticism and Risk of #Parkinson’s Disease: A Meta‐Analysis
Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing #Parkinson Disease
Parkinson disease (PD) is a common neurodegenerative disease. A treatment that prevents or delays development of PD is a critical unmet need. Terazosin and closely related drugs were recently discovered to enhance glycolysis and reduce PD progression in animal models and human clinical databases.. ..A cohort of 52 365 propensity score–matched pairs of terazosin/doxazosin/alfuzosin and tamsulosin… Continue reading Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing #Parkinson Disease
2 Medical News 