It has been reported that migraine is more common in patients with inflammatory bowel disease (IBD) than in general. However, the impact of migraine on the development of IBD has not yet been elucidated. The aim of this study was to determine the association between migraine and the development of IBD. This nationwide population-based cohort… Continue reading #Migraine is associated with the development of adult patients with inflammatory #bowel disease: a nationwide, population-based study
Tag: IBD
Risk of #Inflammatory #Bowel Disease in Patients With #Atopic Dermatitis
Data on the association between atopic dermatitis (AD) and inflammatory bowel disease (IBD) are inconsistent. Few studies have examined the association of AD or AD severity with risk of ulcerative colitis (UC) and Crohn disease (CD) separately.Objectives To examine the risk of new-onset IBD, UC, and CD in children and adults with AD. Design, Setting, and… Continue reading Risk of #Inflammatory #Bowel Disease in Patients With #Atopic Dermatitis
Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage
The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage. The diet of high-income countries contains increasing amounts of sugar, such as sucrose. ISCs and TA cells are sensitive to dietary metabolites, but whether excess sugar affects their function directly… Continue reading Excess Dietary Sugar Alters Colonocyte Metabolism and Impairs the Proliferative Response to Damage
Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis
Experimental mouse models are central to basic biomedical research; however, variability exists across genetically identical mice and mouse facilities making comparisons difficult. Whether specific indigenous gut bacteria drive immunophenotypic variability in mouse models of human disease remains poorly understood. We performed a large-scale experiment using 579 genetically identical laboratory mice from a single animal facility, designed… Continue reading Identification of gut microbial species linked with disease variability in a widely used mouse model of colitis
Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
The microbiota modulates gut immune homeostasis. Bacteria influence the development and function of host immune cells, including T helper cells expressing interleukin-17A (TH17 cells). We previously reported that the bile acid metabolite 3-oxolithocholic acid (3-oxoLCA) inhibits TH17 cell differentiation1. Although it was suggested that gut-residing bacteria produce 3-oxoLCA, the identity of such bacteria was unknown,… Continue reading Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of various diseases including Crohn’s disease (CD). Factors that lead to the development of impaired autophagy during intestinal inflammation remain largely unexplored. Here, we report the impact of the interaction between serotonin [5-hydroxytryptamine;(5-HT)] and autophagy in colitis in mouse and human studies. In mice,… Continue reading Disruption of autophagy by increased #5-HT alters gut microbiota and enhances susceptibility to experimental colitis and #Crohn’s disease
Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Clostridioides difficile infection (CDI) is a major cause of morbidity among patients with inflammatory bowel disease (IBD). Diagnostic biomarkers for early detection of CDI are needed in clinical practice. The relationship between serum procalcitonin and CDI in IBD patients has not been investigated so far. Therefore, we aimed to evaluate the usefulness of measuring serum… Continue reading Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Locking down access to the brainInflammatory bowel disease is best known for intestinal symptoms but can also cause a variety of extraintestinal manifestations in other organs. It can also be associated with cognitive and psychiatric effects, including anxiety and depression. Using mouse models of intestinal inflammation, Carloni et al. uncovered a potential pathogenic link between… Continue reading Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Association of ultra-processed #food intake with risk of #inflammatory bowel disease: prospective cohort study
To evaluate the relation between intake of ultra-processed food and risk of inflammatory bowel disease (IBD). Design Prospective cohort study. Setting 21 low, middle, and high income countries across seven geographical regions (Europe and North America, South America, Africa, Middle East, south Asia, South East Asia, and China). Participants 116 087 adults aged 35-70 years with… Continue reading Association of ultra-processed #food intake with risk of #inflammatory bowel disease: prospective cohort study
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