Intravenous zoledronate reduces fracture risk (5mg at 18mo intervals) and prevents bone loss (doses of 1-5mg for 3 to >5y), but the duration of action of a single 5mg dose and the effects of lower doses beyond 5 years are unknown. We report the second open-label extension (years 5-10) of a 2y randomized, multidose, placebo-controlled, double-blinded… Continue reading #Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial
Tag: hip
Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial
Osteolysis causes recurrent pain and disability after total hip arthroplasty. We investigated the effect of the human monoclonal antibody denosumab on osteolytic lesion activity in patients undergoing revision total hip arthroplasty surgery to show the biological proof of concept for a non-surgical treatment for the disease.. Findings Between Dec 12, 2012, and June 24, 2018,… Continue reading Effect of #denosumab on osteolytic lesion activity after total #hip arthroplasty: a single-centre, randomised, double-blind, placebo-controlled, proof of concept trial
#Vegetarian and #vegan diets and risks of total and site-specific #fractures: results from the prospective EPIC-Oxford study
There is limited prospective evidence on possible differences in fracture risks between vegetarians, vegans, and non-vegetarians. We aimed to study this in a prospective cohort with a large proportion of non-meat eaters.. ..Compared with meat eaters and after adjustment for socio-economic factors, lifestyle confounders, and body mass index (BMI), the risks of hip fracture were… Continue reading #Vegetarian and #vegan diets and risks of total and site-specific #fractures: results from the prospective EPIC-Oxford study
Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort
To determine whether chronic obstructive pulmonary disease (COPD) is a risk factor for hip fracture and identify other factors associated with hip fracture. Patients and Methods: Observational nested case–control study was conducted in Aragon, Spain in 2010. We included COPD patients aged > 40 years, in the EpiChron cohort. Each COPD patient was matched for… Continue reading Chronic Obstructive #Pulmonary Disease and Incidence of #Hip Fracture: A Nested Case–Control Study in the EpiChron Cohort
Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis
Musculoskeletal pain is a common cause of pain in adolescence and can be an important predictor of future pain. The prevalence of hip or groin pain that could potentially affect different adolescent populations has not yet been systematically reviewed. This systematic review aimed to determine the prevalence of hip or groin pain in this population.… Continue reading Prevalence of Hip or Groin Pain in Adolescents: A Systematic Review and Meta‐Analysis
Subcutaneous #tanezumab for #osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period
..Patients were randomised to tanezumab 2.5 mg or 5 mg subcutaneously or matching placebo every 8 weeks (three doses). ..From March 2016 to December 2017, 849 patients were randomised and evaluated (placebo n=282, tanezumab 2.5 mg n=283, tanezumab 5 mg n=284). At week 24, there was a statistically significant improvement from baseline for tanezumab 5 mg compared with placebo… Continue reading Subcutaneous #tanezumab for #osteoarthritis of the hip or knee: efficacy and safety results from a 24-week randomised phase III study with a 24-week follow-up period
Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
To assess whether acute kidney injury (AKI) is associated with more complications and higher healthcare utilization in people undergoing primary total hip arthroplasty (THA).. ..Adjusted for age, gender, race, income, underlying diagnosis, medical comorbidity, and the insurance payer, AKI in people who underwent primary THA was associated with significantly higher OR (95% CI) of (1)… Continue reading Acute #kidney injury after primary total hip #arthroplasty: a risk multiplier for complication, mortality, and healthcare utilization
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