Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used. METHODS We performed a pragmatic, randomized trial comparing one-step screening (i.e., a glucose-tolerance test in which… Continue reading A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
Tag: gestational
PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against #gestational #diabetes in mice and humans
Pregnancy is a physiological state of continuous adaptation to changing maternal and fetal nutritional needs, including a reduction of maternal insulin sensitivity allowing for appropriately enhanced glucose availability to the fetus. However, excessive insulin resistance in conjunction with insufficient insulin secretion results in gestational diabetes mellitus (GDM), greatly increasing the risk for pregnancy complications and… Continue reading PAPPA-mediated adipose tissue remodeling mitigates insulin resistance and protects against #gestational #diabetes in mice and humans
Maternal #Hypertensive Pregnancy Disorders and #Mental Disorders in Children
The associations of maternal hypertensive pregnancy disorders with offspring mental disorders remain unclear. We examined whether maternal hypertensive disorders and maximum blood pressure during pregnancy predict offspring childhood mental disorders, whether the associations are independent of maternal and paternal mental disorders and paternal hypertensive disorders, independent of or additive with maternal early pregnancy overweight/obesity and… Continue reading Maternal #Hypertensive Pregnancy Disorders and #Mental Disorders in Children
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
1 in 5 women report cannabis use during pregnancy, with nausea cited as their primary motivation. Studies show that (-)-△9–tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in cannabis, causes fetal growth restriction, though the mechanisms are not well understood.. The goal of this study was to examine, in rats, the impact of maternal Δ9-THC exposure on… Continue reading Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
To evaluate the associations between maternal diabetes diagnosed before or during pregnancy and early onset cardiovascular disease (CVD) in offspring during their first four decades of life. ..Offspring of mothers with diabetes had a 29% increased overall rate of early onset CVD (hazard ratio 1.29 (95% confidence interval 1.21 to 1.37); cumulative incidence among offspring… Continue reading Maternal #diabetes during pregnancy and early onset of #cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study
When adjusting for potential confounders, AD use was associated with an increased risk of GDM (aOR 1.19, 95% CI 1.08 to 1.30); venlafaxine (aOR 1.27, 95% CI 1.09 to 1.49) and amitriptyline (aOR 1.52, 95% CI 1.25 to 1.84) were also associated with an increased risk of GDM. Moreover, the risk of GDM was increased with longer duration… Continue reading Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study
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