Importance Estimating global lives and life-years saved is important to put into perspective the benefits of COVID-19 vaccination. Prior studies have focused mainly on the pre-Omicron period or only on specific regions, and lack crucial life-year calculations and often depend on strong modeling assumptions with unaccounted uncertainty.Objective To calculate the lives and life-years saved by… Continue reading Global Estimates of #Lives and Life-Years Saved by #COVID-19 #Vaccination During 2020-2024
Tag: covid-19
Association Between #COVID-19 #Vaccination and #Neuropsychiatric Conditions
Introduction: This study explores the potential associations between COVID-19 vaccination and neuropsychiatric conditions. Methods: Data were collected from the CDC and FDA. The VAERS database was queried from January 1, 1990, to December 27, 2024, for adverse events (AEs) involving neuropsychiatric complications following COVID-19 vaccination. The timeframe included 420 months for all vaccines except COVID-19… Continue reading Association Between #COVID-19 #Vaccination and #Neuropsychiatric Conditions
Age-adjusted non-COVID-19 #mortality rates according to the #COVID-19 vaccination status
Excess mortality has been observed in several countries since 2021 and has not yet been explained. The aim of this study was to determine whether the age-adjusted mortality rates of non-COVID-19 deaths differed between those who had received one, two, three or four doses compared with the unvaccinated. Data were obtained from the Office for… Continue reading Age-adjusted non-COVID-19 #mortality rates according to the #COVID-19 vaccination status
Deaths “due to” #COVID-19 and deaths “with” COVID-19 during the #Omicron variant surge, among hospitalized patients in seven tertiary-care hospitals, Athens, Greece
In Greek hospitals, all deaths with a positive SARS-CoV-2 test are counted as COVID-19 deaths. Our aim was to investigate whether COVID-19 was the primary cause of death, a contributing cause of death or not-related to death amongst patients who died in hospitals during the Omicron surge and were registered as COVID-19 deaths. Additionally, we… Continue reading Deaths “due to” #COVID-19 and deaths “with” COVID-19 during the #Omicron variant surge, among hospitalized patients in seven tertiary-care hospitals, Athens, Greece
Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
AbstractThe COVID-19 vaccine is a significant technological advancement with widespread global use. However, its effect on cancer immunity, particularly with repeated vac-cinations, remains unclear. We aimed to investigate the relationship between repeated vaccinations and pancreatic cancer (PC) prognosis. Additionally, we examined serum IgG4 levels, known to be an immune suppressor and increased with repeated vac-cinations.… Continue reading Repeated #COVID-19 #Vaccination as a Poor Prognostic Factor in Pancreatic #Cancer: A Retrospective, Single-Center Cohort Study
COVID-19 #vaccines and #adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
AbstractBackground: The Global COVID Vaccine Safety (GCoVS) Project, established in 2021 under the multinational Global Vaccine Data Network™ (GVDN®), facilitates comprehensive assessment of vaccine safety. This study aimed to evaluate the risk of adverse events of special interest (AESI) following COVID-19 vaccination from 10 sites across eight countries.Methods: Using a common protocol, this observational cohort… Continue reading COVID-19 #vaccines and #adverse events of special interest: A multinational Global Vaccine Data Network (GVDN) cohort study of 99 million vaccinated individuals
The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19… Continue reading The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Background Children and adolescents in England were offered BNT162b2 as part of the national COVID-19 vaccine roll out from September 2021. We assessed the safety and effectiveness of first and second dose BNT162b2 COVID-19 vaccination in children and adolescents in England.Methods With the approval of NHS England, we conducted an observational study in the OpenSAFELY-TPP… Continue reading OpenSAFELY: Effectiveness of #COVID-19 #vaccination in #children and sadolescents
Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
Background: The COVID-19 pandemic adversely affected the severity and prognosis of patients with acute myocardial infarction (MI) caused by atherothrombosis (type 1 MI). The effect, if any, of COVID-19 vaccination and natural SARS-CoV2 serologic immunity in these patients is unclear. Our aim was to analyze the association between the severity and outcome of patients with type… Continue reading Association of #SARS-CoV-2 immunoserology and #vaccination status with #myocardial infarction severity and outcome
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