Tag: Brain

Prescribed Drug Use and #Aneurysmal Subarachnoid #Hemorrhage IncidenceA Drug-Wide Association Study

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Background and ObjectivesCurrent benefits of invasive intracranial aneurysm treatment to prevent aneurysmal subarachnoid hemorrhage (aSAH) rarely outweigh treatment risks. Most intracranial aneurysms thus remain untreated. Commonly prescribed drugs reducing aSAH incidence may provide leads for drug repurposing. We performed a drug-wide association study (DWAS) to systematically investigate the association between commonly prescribed drugs and aSAH… Continue reading Prescribed Drug Use and #Aneurysmal Subarachnoid #Hemorrhage IncidenceA Drug-Wide Association Study

Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice

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Although the brain can discriminate between various sweet substances, the underlying neural mechanisms of this complex behavior remain elusive. This study examines the role of the anterior paraventricular nucleus of the thalamus (aPVT) in governing sweet preference in mice. We fed the mice six different diets with equal sweetness for six weeks: control diet (CD),… Continue reading Neuronal activity in the anterior paraventricular nucleus of thalamus positively correlated with #sweetener consumption in mice

Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography

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n the ever-evolving landscape of medical diagnostics, cerebral angiography stands out as a powerful tool that allows physicians to delve into the intricate network of blood vessels within the brain. As physicians, our commitment to accurate diagnosis and comprehensive patient care often leads us to explore advanced imaging techniques. In this blog post, we will… Continue reading Navigating the #Vasculature: A Physician’s Guide to Cerebral #Angiography

Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses

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Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: ‘starch-free or reduced-starch’ (subtype 1), ‘vegetarian’ (subtype 2), ‘high protein and low fiber’ (subtype 3) and ‘balanced’ (subtype 4). These subtypes varied… Continue reading Associations of #dietary patterns with #brain health from behavioral, neuroimaging, biochemical and genetic analyses

Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain

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#Emotion and #perception are tightly intertwined, as affective experiences often arise from the appraisal of sensory information. Nonetheless, whether the brain encodes emotional instances using a sensory-specific code or in a more abstract manner is unclear. Here, we answer this question by measuring the association between emotion ratings collected during a unisensory or multisensory presentation… Continue reading Dissecting abstract, modality-specific and experience-dependent coding of affect in the human #brain

Do interventions for mood improve #inflammatory biomarkers in inflammatory #bowel disease?: A systematic review and meta-analysis

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BackgroundPsychoneuroimmunological mechanisms and the gut-brain axis appear relevant to disease activity and progression in Inflammatory Bowel Disease (IBD). A recent review showed no effect of psychological therapies on self-reported disease activity in IBD. This meta-analysis aims to establish whether interventions targeting mood outcomes (e.g., depression, anxiety and stress) impact inflammation levels in IBD and possible… Continue reading Do interventions for mood improve #inflammatory biomarkers in inflammatory #bowel disease?: A systematic review and meta-analysis

OXR1 maintains the retromer to delay brain #aging under #dietary restriction

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Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediated lifespan extension in female flies. We found that mtd/OXR1 expression declines with age and it interacts with the retromer, which regulates trafficking of proteins and lipids.… Continue reading OXR1 maintains the retromer to delay brain #aging under #dietary restriction

Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice 

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Caffeine has significant effects on neurovascular activity and behavior throughout the sleep–wake cycle. We used a minimally invasive microchip/video system to continuously record effects of caffeine in the drinking water of freely behaving mice. Chronic caffeine shifted both rest and active phases by up to 2 h relative to the light–dark cycle in a dose-dependent fashion.… Continue reading Effects of chronic #caffeine on patterns of #brain blood flow and behavior throughout the sleep–wake cycle in freely behaving mice