Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023) In the first half of the sixteenth century, the Low Countries saw the rise of a lively market for practical and instructive books that targeted non-specialist readers. This study shows how woodcuts in vernacular books… Continue reading Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023)
#Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Although hormone therapy (HT) in perimenopausal women is associated with increased risk for venous thromboembolism (VTE), it is unclear to what extent statins may mitigate this HT-associated risk.Objective To estimate VTE risk in women aged 50 to 64 years taking HT with or without statins.Design, Setting, and Participants This nested case-control study analyzed data from a commercially… Continue reading #Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To evaluate the safety of high-dose NR therapy, we conducted a single-center, randomized, placebo-controlled, double-blind,… Continue reading NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Deciphering #Tachypnea: A Physician’s Perspective on Pathophysiology and Implications
Tachypnea, a rapid and shallow breathing pattern, is a clinical sign that beckons the attention of physicians, serving as a vital indicator of an underlying physiological disturbance. As physicians, our keen understanding of the pathophysiology behind tachypnea is pivotal in unraveling its implications and guiding us toward the appropriate diagnostic and therapeutic interventions. Join me… Continue reading Deciphering #Tachypnea: A Physician’s Perspective on Pathophysiology and Implications
Detecting Severe #AKI in Hospitalized Patients with Biomarkers of Kidney Injury – A Physician’s Guide to Precision Diagnosis
Acute Kidney Injury (AKI) is a critical concern in hospitalized patients, associated with increased morbidity, mortality, and healthcare costs. The ability to detect AKI early and accurately is paramount for timely intervention and improved patient outcomes. In this post, I embark on a physician’s journey to explore the world of biomarkers for kidney injury, shedding… Continue reading Detecting Severe #AKI in Hospitalized Patients with Biomarkers of Kidney Injury – A Physician’s Guide to Precision Diagnosis
Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
Many acute treatment options exist for migraine. However, large-scale, head-to-head comparisons of treatment effectiveness from real-world patient experience reports are lacking.MethodsThis is a retrospective analysis of 10,842,795 migraine attack records extracted from an e-diary smartphone application between June 30, 2014, and July 2, 2020. We analyzed 25 acute medications among seven classes- acetaminophen, NSAIDs, triptans,… Continue reading Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
Balancing Act – Navigating Acid-Base Disorders in Cirrhosis Patients – A Physician’s Perspective
Cirrhosis, a complex and progressive liver disease, poses myriad challenges for physicians. Among its many complications, acid-base disorders often emerge as a perplexing aspect of patient care. Understanding the intricate interplay between liver dysfunction, acid-base balance, and the clinical implications thereof is pivotal for physicians managing cirrhosis patients. In this post, I embark on a… Continue reading Balancing Act – Navigating Acid-Base Disorders in Cirrhosis Patients – A Physician’s Perspective
Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
Nonalcoholic fatty liver disease (NAFLD)-related fibrosis is heritable, but it is unclear how family history may be used to identify first-degree relatives with advanced fibrosis. We aimed to develop and validate a simple risk score to identify first-degree relatives of probands who have undergone assessment of liver fibrosis who are at higher risk of NAFLD… Continue reading Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
#Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote #behavioral stress resilience
The gut microbiome consists of trillions of bacteria, fungi, and viruses that inhabit the digestive tract. These communities are sensitive to disruption from environmental exposures ranging from diet changes to illness. Disruption of the community of lactic acid producing bacteria, Lactobaccillacea, has been well documented in mood disorders and stress exposure. In fact, oral supplement with many Lactobacillus species… Continue reading #Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote #behavioral stress resilience
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