Early discontinuation of dual antiplatelet therapy (DAPT) within 3 months after implantation of drug-eluting stents may reduce bleeding risk without increasing ischaemic events. This study aimed to assess whether 3-month DAPT is as safe as the conventional 12-month regimen in patients treated with Firehawk stents, which have demonstrated 99.9% reendothelialisation at 3 months by optical… Continue reading Three vs 12-month #DAPT after implantation of biodegradable-polymer sirolimus-eluting coronary #stent : a randomised clinical trial
Improving non-invasive #glucose estimation with monthly calibrated #photoplethysmography and implicit #HbA1c
Background: Most noninvasive blood glucose technologies, especially wearable photoplethysmography devices, require multiple calibrations and are often limited to narrow cohorts such as unmedicated or mild cases. We assess whether a single pretest once per month can meet clinical accuracy while broadening applicability through cohort-specific models.Methods: We develop models for three groups: (i) individuals not using… Continue reading Improving non-invasive #glucose estimation with monthly calibrated #photoplethysmography and implicit #HbA1c
#Acupuncture for #fibromyalgia syndrome: an overview of systematic reviews and meta-analyses
Objective: Numerous systematic reviews (SRs) and meta-analyses (MAs) have investigated the clinical effectiveness of acupuncture therapy (AT) for fibromyalgia syndrome (FMS); however, the quality and consistency of the evidence remain unclear. This study aimed to evaluate the methodological quality and strength of evidence in published SRs and MAs on the efficacy and safety of AT… Continue reading #Acupuncture for #fibromyalgia syndrome: an overview of systematic reviews and meta-analyses
The effectiveness of Zhi-Shi plaster acupoint therapy combined with lactulose in the treatment of geriatrics functional constipation: a randomized controlled trial
Objective: This study aimed to evaluate the effectiveness and adverse effects of Zhi-Shi plaster acupoint therapy combined with Lactulose in the Treatment of geriatrics Functional Constipation.Methods: A total of 62 geriatrics Functional Constipation patients were randomly assigned to the intervention group (n = 31) and control group (n = 31). The intervention group received oral lactulose (20 mL daily for… Continue reading The effectiveness of Zhi-Shi plaster acupoint therapy combined with lactulose in the treatment of geriatrics functional constipation: a randomized controlled trial
Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections
Staphylococcus aureus small-colony variants (SCVs) are unique phenotypic forms that significantly contribute to the development of chronic, recurrent, and treatment-refractory infections. These variants arise from metabolic defects, most commonly in the menadione, hemin, or thymidine biosynthetic pathways, leading to slow growth, atypical colony morphology, and altered virulence expression. The ability of these bacteria to persist… Continue reading Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections
Real-World outcomes of oral #anticoagulation in patients with atrial #fibrillation at high risk of both #bleeding anand Asia-Pacificd stroke: observational evidence from three international registries from middle East, Europe
To evaluate the clinical course of patients with AF at high risk for both bleeding and stroke, according to OAC use. Data were analysed from three registries across the Middle East, Europe, and Asia-Pacific regions. The study only included 'high risk' patients with AF and CHA₂DS₂-VASc scores ≥ 2 and HAS-BLED scores ≥ 3, who… Continue reading Real-World outcomes of oral #anticoagulation in patients with atrial #fibrillation at high risk of both #bleeding anand Asia-Pacificd stroke: observational evidence from three international registries from middle East, Europe
#Wearable -derived heart rate variability and sleep monitoring as predictors of #mood episodes in bipolar disorder: a case report
Background: Bipolar disorder is a chronic psychiatric condition characterized by alternating episodes of mania and depression, and the prediction and management of mood episodes remain significant clinical challenges. Traditional assessments of mood states have largely relied on subjective methods, such as clinical interviews and self-report questionnaires, which present limitations in terms of early detection and… Continue reading #Wearable -derived heart rate variability and sleep monitoring as predictors of #mood episodes in bipolar disorder: a case report
An Analysis of Initial Loop #Diuretic Dosing Strategies and Its Association with Time to #Decongestion
Background: There is currently a lack of evidence on the optimal loop diuretic dosing strategy in cases of acute decompensated heart failure (ADHF). Current consensus recommendations suggest starting with a dose of at least 2 times the patient’s home loop diuretic dose. Objective: This study assessed whether higher initial loop diuretic doses are associated with… Continue reading An Analysis of Initial Loop #Diuretic Dosing Strategies and Its Association with Time to #Decongestion
Effect of Sodium-Glucose Co-transporter 2 ( #SGLT2 ) Inhibitors in the Management of #Hyponatremia Associated With Syndrome of Inappropriate Antidiuresis
AbstractBackground: Hyponatremia due to syndrome of inappropriate antidiuresis (SIAD) is a common and challenging electrolyte disorder, particularly in hospitalized and elderly patients. Conventional treatments, such as fluid restriction and vasopressin receptor antagonists, have limitations related to efficacy, tolerance, availability, and cost. Sodium-glucose co-transporter 2 inhibitors (SGLT2i), primarily used for type 2 diabetes, have shown potential… Continue reading Effect of Sodium-Glucose Co-transporter 2 ( #SGLT2 ) Inhibitors in the Management of #Hyponatremia Associated With Syndrome of Inappropriate Antidiuresis
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