Identities of functional pSer/Thr.Pro protein substrates of the PIN1 prolyl isomerase and its effects on downstream signaling in bladder carcinogenesis remain largely unknown. Phenotypically, we found that PIN1 positively regulated bladder cancer cell proliferation, cell motility and urothelium clearance capacity in vitro and controlled tumor growth and potential metastasis in vivo. Mechanistically, we observed a… Continue reading PIN1 prolyl isomerase promotes initiation and progression of #bladder cancer through the SREBP2-mediated #cholesterol biosynthesis pathway
Category: Urology
Dietary pro-oxidant therapy by a vitamin #K precursor targets PI 3-kinase VPS34 function
In light of emerging evidence that antioxidants can have cancer-promoting effects, Swamynathan et al. tested potential pro-oxidant interventions (see the Perspective by Pannia and Dowling). In particular, the authors focused on menadione sodium bisulfite, a water-soluble precursor of vitamin K. As the authors anticipated, this menadione derivative suppressed prostate cancer growth. The researchers then examined… Continue reading Dietary pro-oxidant therapy by a vitamin #K precursor targets PI 3-kinase VPS34 function
Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of Terazosin, Doxazosin, or Alfuzosin Use and Risk of #Dementia With #Lewy Bodies in Men
Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
Background and ObjectivesTerazosin, doxazosin, and alfuzosin (Tz/Dz/Az) are α-1 adrenergic receptor antagonists that also bind to and activate a key adenosine triphosphate (ATP)–producing enzyme in glycolysis. It is hypothesized that the increase in energy availability in the brain may slow or prevent neurodegeneration, potentially by reducing the accumulation of alpha-synuclein. Recent work has suggested a… Continue reading Association of #Terazosin, #Doxazosin, or #Alfuzosin Use and Risk of #Dementia With Lewy Bodies in Men
#Prostate Safety Events During #Testosterone Replacement Therapy in Men With HypogonadismA Randomized Clinical Trial
Importance The effect of testosterone replacement therapy (TRT) on the risk of prostate cancer and other adverse prostate events is unknown.Objective To compare the effect of TRT vs placebo on the incidences of high-grade prostate cancers (Gleason score ≥4 + 3), any prostate cancer, acute urinary retention, invasive prostate procedures, and pharmacologic treatment for lower urinary tract… Continue reading #Prostate Safety Events During #Testosterone Replacement Therapy in Men With HypogonadismA Randomized Clinical Trial
Association between self-reported mobile #phone use and the #semen quality of young men
To investigate the association between mobile phone exposure and semen parameters.A nationwide cross-sectional study.SettingAndrology laboratories in close proximity to 6 army recruitment centers.PatientsIn total, 2886 men from the general Swiss population, 18–22 years old, were recruited between 2005 and 2018 during military conscription.InterventionParticipants delivered a semen sample and completed a questionnaire on health and lifestyle,… Continue reading Association between self-reported mobile #phone use and the #semen quality of young men
Effect of aerobic #exercise on #erectile function: systematic review and meta-analysis of randomized controlled trials
The health benefits of regular aerobic exercise are well established, although there is limited high-quality evidence regarding its impact on erectile function.AimTo determine the effect of aerobic exercise on erectile function in men and to identify factors that may influence this effect.MethodsThis systematic review and meta-analysis included randomized controlled trials that evaluated the effects of… Continue reading Effect of aerobic #exercise on #erectile function: systematic review and meta-analysis of randomized controlled trials
The #sex gap in #bladder cancer survival — a missing link in bladder #cancer care?
The differences in bladder cancer outcomes between the sexes has again been highlighted. Uncommon among cancers, bladder cancer outcomes are notably worse for women than for men. Furthermore, bladder cancer is three to four times more common among men than among women. Factors that might explain these sex differences include understanding the importance of haematuria… Continue reading The #sex gap in #bladder cancer survival — a missing link in bladder #cancer care?
Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood
Background and ObjectivesVascular theories of cognitive aging have focused on macrovascular changes and cognitive decline. However, according to the artery-size hypothesis, microvascular changes, such as those that underlie changes in erectile function, may also play an important role in contributing to cognitive decline. Thus, we examined associations between erectile function, sexual satisfaction, and cognition starting… Continue reading Erectile Function, Sexual Satisfaction, and Cognitive Decline in Men From Midlife to Older Adulthood
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