Osteoarthritis (OA) is a degenerative bone and joint disease characterized by decreased cartilage lubrication, leading to continuous wear and ultimately irreversible damage. This situation is particularly challenging for early-stage OA, as current bio-lubricants lack precise targeting for small inflammatory lesions. In this work, an antibody-mediated targeting hydrogel microspheres (HMS) is developed to precisely lubricate the… Continue reading Precise Lubrication and Protection of #Cartilage Damage by Targeting #Hydrogel Microsphere
Category: Orthopedy
Effectiveness and cost-effectiveness of an individualised, progressive #walking and education intervention for the prevention of low back #pain recurrence in Australia (WalkBack): a randomised controlled trial
BackgroundRecurrence of low back pain is common and a substantial contributor to the disease and economic burden of low back pain. Exercise is recommended to prevent recurrence, but the effectiveness and cost-effectiveness of an accessible and low-cost intervention, such as walking, is yet to be established. We aimed to investigate the clinical effectiveness and cost-effectiveness… Continue reading Effectiveness and cost-effectiveness of an individualised, progressive #walking and education intervention for the prevention of low back #pain recurrence in Australia (WalkBack): a randomised controlled trial
An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding to six proteins, reached AUC 77% probability to distinguish those who developed OA from age-matched individuals who did not develop OA up to 8 years… Continue reading An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Chronic musculoskeletal pain (CMP), a prevalent and heterogeneous condition characterized by persistent pain in various body parts, is a leading cause of disability worldwide and greatly affects a patient’s brain. Apart from experiencing pain, older adults with CMP also have accelerated cognitive decline and higher dementia risk with limited understanding of biological mechanism underlying the… Continue reading Morphological and genetic decoding shows heterogeneous patterns of brain aging in chronic #musculosckeletal pain
Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
BackgroundCaffeine is one of the most utilized drugs in the world, yet its clinical effects are not fully understood. Circulating caffeine levels are influenced by the interplay between consumption behaviour and metabolism. This study aimed to investigate the effects of circulating caffeine levels by considering genetically predicted variation in caffeine metabolism.MethodsLeveraging genetic variants related to… Continue reading Genetic investigation into the broad health implications of #caffeine: evidence from phenome-wide, proteome-wide and metabolome-wide Mendelian randomization
#Dietary inflammatory index and MRI-detected #knee structural change and pain: a 10.7-year follow-up study
To determine whether the dietary inflammatory index (DII®) scores were associated with knee structural changes and pain over a 10.7-year follow-up.MethodsThis study utilised data from a prospective population-based cohort study (mean age 63 years, 51% female) in which 1,099, 875, 768 and 566 participants completed assessments at baseline, 2.6, 5.1 and 10.7 years, respectively. T1-weighted and T2-weighted… Continue reading #Dietary inflammatory index and MRI-detected #knee structural change and pain: a 10.7-year follow-up study
Silver─Gallium Nano-Amalgamated Particles as a Novel, Biocompatible Solution for #Antibacterial Coatings
Bacterial infections account for countless deaths globally. Antibiotics are the primary countermeasure; however, the alarming spread of antibiotic-resistant strains necessitates alternative solutions. Silver and silver compounds have emerged as promising antibacterial agents. However, issues related to cytotoxicity and genotoxicity of silver remain concern. To overcome these challenges, this proposes an easy-to-control and straightforward method to… Continue reading Silver─Gallium Nano-Amalgamated Particles as a Novel, Biocompatible Solution for #Antibacterial Coatings
Lower serum #testosterone is associated with increased likelihood of #arthritis
Studies have suggested that serum testosterone levels may be strongly correlated with the pathogenesis of arthritis. Therefore, the aim of this study was to assess the relationship between serum testosterone levels and arthritis in US adults using the National Health and Nutrition Examination Survey (NHANES). We used the database from NHANES, 2013–2016 to perform a… Continue reading Lower serum #testosterone is associated with increased likelihood of #arthritis
A two-cohort study on the association between the gut #microbiota and #bone density, microarchitecture, and strength
The gut microbiome affects the inflammatory environment through effects on T-cells, which influence the production of immune mediators and inflammatory cytokines that stimulate osteoclastogenesis and bone loss in mice. However, there are few large human studies of the gut microbiome and skeletal health. We investigated the association between the human gut microbiome and high resolution… Continue reading A two-cohort study on the association between the gut #microbiota and #bone density, microarchitecture, and strength
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