Early shift to oral #antibiotic treatment for pyogenic vertebral #osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial

BackgroundThe current Danish National Guideline (DNG) for treatment of pyogenic vertebral osteomyelitis (PVO) recommends 6 weeks antibiotic (AB) treatment, with a 2-week intravenous (IV) AB lead-in followed by 4 weeks oral AB for uncomplicated PVO, and 12 weeks AB treatment with a 4-week IV AB lead-in followed by 8 weeks oral AB for complicated PVO.The… Continue reading Early shift to oral #antibiotic treatment for pyogenic vertebral #osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial

Comparative efficacy and safety of #exercise modalities in #knee #osteoarthritis: systematic review and network meta-analysis

Objective To assess the efficacy and safety of various exercise modalities as therapeutic interventions for managing knee osteoarthritis.Design Systematic review with network meta-analysis.Data sources PubMed, Embase, Cochrane Library, Web of Science, CINAHL, PsycINFO, AMED, PEDro, Scopus, ClinicalTrials.gov, ICTRP, and ClinicalTrialsRegister.eu from database inception to August 2024.Eligibility criteria for selecting studies Randomised controlled trials comparing different… Continue reading Comparative efficacy and safety of #exercise modalities in #knee #osteoarthritis: systematic review and network meta-analysis

AI in Hand #Surgery: Assessing Large Language Models in the Classification and Management of #Hand Injuries

AbstractBackground: OpenAI's ChatGPT (San Francisco, CA, USA) and Google's Gemini (Mountain View, CA, USA) are two large language models that show promise in improving and expediting medical decision making in hand surgery. Evaluating the applications of these models within the field of hand surgery is warranted. This study aims to evaluate ChatGPT-4 and Gemini in… Continue reading AI in Hand #Surgery: Assessing Large Language Models in the Classification and Management of #Hand Injuries

[Thermo- #electroacupuncture at #yaosanzhen for chronic #lumbar #muscle strain of cold dampness: a randomized controlled trial]

Objective: To compare the clinical efficacy between thermo-electroacupuncture at yaosanzhen and oral celecoxib in the treatment of chronic lumbar muscle strain with cold dampness.Methods: A total of 80 patients with chronic lumbar muscle strain of cold dampness were randomly divided into an observation group (40 cases, 1 case dropped out) and a control group (40… Continue reading [Thermo- #electroacupuncture at #yaosanzhen for chronic #lumbar #muscle strain of cold dampness: a randomized controlled trial]

Comparative efficacy of #Tai Chi versus #balance training on functional performance and #postural control during sit and stand transitions in individuals with #knee #osteoarthritis: A randomized trial

Objectives: This study evaluates the efficacy of Tai Chi versus balance training on functional performance and postural control during sit and stand transitions in individuals with knee osteoarthritis.Design: Single-blind randomized trial.Methods: Sixty-nine patients with knee osteoarthritis were assigned to Tai Chi (n = 35) or balance training (n = 34) for 12 weeks. Assessments were… Continue reading Comparative efficacy of #Tai Chi versus #balance training on functional performance and #postural control during sit and stand transitions in individuals with #knee #osteoarthritis: A randomized trial

LBA 06 – Clinical Effectiveness of Single Course Low-Dose #Radiation Therapy in #Knee #Osteoarthritis: Short-term Results from the Randomized, Sham-Controlled Trial

Low-dose radiation therapy (LDRT) has been historically used as a non-pharmacologic option for osteoarthritis (OA), but solid evidence from randomized trials is still limited.Materials/Methods: In this multicenter, randomized, sham-controlled trial, 114 patients with knee OA were allocated to receive sham irradiation, total 0.3 Gy/6 fractions, or total 3 Gy/6 fractions. The main inclusion criteria are… Continue reading LBA 06 – Clinical Effectiveness of Single Course Low-Dose #Radiation Therapy in #Knee #Osteoarthritis: Short-term Results from the Randomized, Sham-Controlled Trial

#Acupuncture appears to be a rapidly effective treatment for #costochondritis

BackgroundTo my knowledge, this is the first case series of costochondritis treated by acupuncture. Eight cases are presented, the majority being seen in primary care.Costochondritis is a debilitating condition characterised by severe anterior or lateral chest pain, associated with tenderness of the second to fifth costochondral (CC) joints. Tietze’s syndrome is a rare variant with… Continue reading #Acupuncture appears to be a rapidly effective treatment for #costochondritis

Personalised #gait retraining for medial compartment #knee #osteoarthritis: a randomised controlled trial

Retraining individuals with medial compartment knee osteoarthritis to walk with a patient-specific change in their foot angle (ie, toe-in or toe-out angle) can reduce excessive joint loading related to disease progression. This study investigated the clinical, biomechanical, and structural efficacy of personalised foot progression angle modifications compared with sham treatment in patients with mild-to-moderate medial… Continue reading Personalised #gait retraining for medial compartment #knee #osteoarthritis: a randomised controlled trial

Volume and Intensity of #Walking and Risk of Chronic Low #Back #Pain

Importance  Chronic low back pain (LBP) is a prevalent and costly condition, and regular physical activity may reduce its risk. Walking is a common and accessible form of physical activity, but its association with the risk of chronic LBP is unclear.Objective  To examine whether accelerometer-derived daily walking volume and walking intensity are associated with the… Continue reading Volume and Intensity of #Walking and Risk of Chronic Low #Back #Pain