Geographic atrophy due to age-related macular degeneration (AMD) is the leading cause of irreversible blindness and affects more than 5 million persons worldwide. No therapies to restore vision in such persons currently exist. The photovoltaic retina implant microarray (PRIMA) system combines a subretinal photovoltaic implant and glasses that project near-infrared light to the implant in… Continue reading #Subretinal Photovoltaic Implant to Restore #Vision in Geographic Atrophy Due to AMD
Category: Ophthalmology
#Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
INTRODUCTIONInvestigations of retinal biomarkers for #Alzheimer's disease (AD) and AD and related dementias (ADRD), has increased significantly. We examine retinal vascular health in a mouse containing the ADRD risk variant Mthfr677C>T to determine if changes in retina mirror similar changes in cerebrovasculature.METHODSMorphology and function of retinal vasculature and neurons were assessed using in vivo imaging,… Continue reading #Retinal vascular dysfunction in the Mthfr677C>T mouse model of #cerebrovascular disease
Digital #Eye #Strain Monitoring for One-Hour #Smartphone Engagement Through Eye Activity Measurement System
Smartphones have revolutionized our daily lives, becoming portable pocket computers with easy internet access. India, the second-highest smartphone and internet user, experienced a significant rise in smartphone usage between 2013 and 2024. Prolonged smartphone use, exceeding 20 min at a time, can lead to physical and mental health issues, including psychophysiological disorders. Digital devices and… Continue reading Digital #Eye #Strain Monitoring for One-Hour #Smartphone Engagement Through Eye Activity Measurement System
Decoding #memory function through naturalistic gaze patterns
#Eye movements are closely linked to encoding and retrieval processes, with changes in viewing behavior reflecting age- and pathology-related memory decline. In the current study, we leveraged this relationship to explore possible gaze-based indicators of memory function. Across two task-free viewing experiments, we investigated changes in naturalistic viewing behavior across five participant groups spanning a… Continue reading Decoding #memory function through naturalistic gaze patterns
Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
Coffee is a popular beverage, and previous cohort studies suggest it may reduce the risk of age-related macular degeneration (AMD). However, confounding factors in these studies necessitate further exploration of causal relationships using advanced methods. We obtained data on coffee consumption from genome-wide association studies (GWAS) and the latest AMD-related GWAS summary data from the… Continue reading Genetic Correlation and Mendelian Randomization Analyses Support Causal Relationships Between Instant #Coffee and Age-Related #Macular Degeneration
#Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related #Macular #Degeneration
Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are extensively used in treating diabetes and obesity, yet little is known about the long-term ocular effects of systemic prolonged exposure.Objective To evaluate the risk of developing neovascular age-related macular degeneration (nAMD) associated with the use of GLP-1 RAs in patients with diabetes.Design, Setting, and Participants This population-based,… Continue reading #Glucagon-Like Peptide-1 Receptor Agonists and Risk of Neovascular Age-Related #Macular #Degeneration
Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
Highlights• Elevated retinal homocysteine is a pathogenic feature of glaucoma• One-carbon metabolism is dysregulated in glaucoma• Oral B6, B9, B12, and choline is neuroprotective in animal modelsSummaryGlaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies. To explore observations of elevated homocysteine… Continue reading Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
#Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk.Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk… Continue reading #Retinal vascular fingerprints predict incident #stroke: findings from the UK Biobank cohort study
High Density #Lipoproteins Associate with Age-Related #Macular Degeneration in the All of Us Research Program
OBJECTIVEExtracellular lipoprotein aggregation is a critical event in AMD pathogenesis. In this study, we sought to analyze associations between clinical and genetic-based factors related to lipoprotein metabolism and risk for age-related macular degeneration (AMD) in the All of Us research program.DESIGNCross-sectional retrospective data analysis.SUBJECTS5028 healthy and 2328 AMD patients from All of Us.METHODSParticipants with and… Continue reading High Density #Lipoproteins Associate with Age-Related #Macular Degeneration in the All of Us Research Program
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