We tested whether genetically proxied non-high-density lipoprotein cholesterol (non-HDL-C)–lowering drug targets reduce risk of all-cause dementia.METHODSWe included 1,091,775 individuals from three prospective general population cohorts with individual-level data and two consortia with summary-level data. We selected genetic variants within HMGCR, NPC1L1, PCSK9, ANGPTL4, LPL, and CETP associated with non-HDL-C. These variants were used as exposures… Continue reading #Cholesterol -lowering drug targets reduce risk of #dementia : Mendelian randomization and meta-analyses of 1 million individuals
Category: Neurology
Slow-Tempo #Music and #Delirium / #Coma -Free Days Among #Older Adults Undergoing Mechanical VentilationA Randomized Clinical Trial
Importance An estimated 70% to 80% of older adults develop delirium in the intensive care unit (ICU).Objective To determine if a slow-tempo music (60-80 beats/min) listening intervention decreases delirium duration, delirium severity, pain, or anxiety in older adults undergoing mechanical ventilation.Design, Setting, and Participants This multicenter randomized clinical trial with concealed outcomes assessments was conducted… Continue reading Slow-Tempo #Music and #Delirium / #Coma -Free Days Among #Older Adults Undergoing Mechanical VentilationA Randomized Clinical Trial
#Macroeconomic #income inequality, #brain structure and function, and #mental health
Income inequality, a structural property of societies characterized by the unequal distribution of resources, is associated with adverse mental health outcomes during adolescence, which is a sensitive period of neurodevelopment. While previous research has explored the impact of individual-level socioeconomic factors on brain structure and function, the neurobiological mechanisms linking structural inequality to mental health… Continue reading #Macroeconomic #income inequality, #brain structure and function, and #mental health
Identification of five #sleep -biopsychosocial profiles with specific neural signatures linking sleep variability with #health, cognition, and lifestyle factors
Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological, and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to identify sleep-biopsychosocial profiles that linked self-reported sleep patterns to inter-individual variability in health, cognition, and lifestyle factors in… Continue reading Identification of five #sleep -biopsychosocial profiles with specific neural signatures linking sleep variability with #health, cognition, and lifestyle factors
Development and validation of blood-based diagnostic biomarkers for #Myalgic #Encephalomyelitis/#Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch® 3-dimensional genomic regulatory immuno-genetic profiling
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating, multifactorial disorder characterised by profound fatigue, post-exertional malaise, cognitive impairments, and autonomic dysfunction. Despite its significant impact on quality of life, ME/CFS lacks definitive diagnostic biomarkers, complicating diagnosis and management. Recent evidence highlights potential blood tests for ME/CFS biomarkers in immunological, genetic, metabolic, and bioenergetic domains. Chromosome… Continue reading Development and validation of blood-based diagnostic biomarkers for #Myalgic #Encephalomyelitis/#Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch® 3-dimensional genomic regulatory immuno-genetic profiling
Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
The pandemic has exacerbated mental health issues across the world. The limited availability of mental health professionals is preventing many from seeking help, which highlights the need for easily available mental health care routines like yoga, breathing, and meditation. A breath-based meditation technique known as Sudarshan Kriya #Yoga (SKY) harnesses the power of breath to… Continue reading Unlocking deep #relaxation: the power of #rhythmic #breathing on brain rhythms
Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related mortality. Generalised—particularly nocturnal—convulsive seizures, longstanding epilepsy, and solitary living have been identified retrospectively as risk factors. No definitive electroclinical biomarkers have been prospectively ascertained. This study aimed to identify SUDEP risk markers using multimodality data with long-term follow-up.MethodsThis prospective, multicentre, observational cohort study,… Continue reading Risk markers for sudden unexpected #death in #epilepsy: an observational, prospective, multicentre cohort study
Associations of Chronic #Insomnia, Longitudinal #Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults
The relationship between insomnia and cognitive decline is poorly understood. We investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults.MethodsFrom the population-based Mayo Clinic Study of Aging, we identified cognitively unimpaired older adults with or without a diagnosis of chronic insomnia who underwent annual neuropsychological assessments (z-scored global cognitive scores… Continue reading Associations of Chronic #Insomnia, Longitudinal #Cognitive Outcomes, Amyloid-PET, and White Matter Changes in Cognitively Normal Older Adults
Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
IntroductionExergame-based training is emerging as the most effective exercise modality for improving cognition, yet its neural correlates remain largely unexplored. This study explored gray matter (GM) and white matter (WM) changes following the addition of ‘Brain-IT’ training to usual care in mild neurocognitive disorder (mNCD) and their associations with cognitive performance changes.MethodsWe included 41 participants… Continue reading Structural brain improvements following individually tailored serious #exergame-based training in mild #neurocognitive disorders: exploratory randomized controlled trial
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