Multiple lines of evidence support the value of moderate fever to host survival, but the mechanisms involved remain unclear. This is difficult to establish in warm-blooded animal models, given the strict programmes controlling core body temperature and the physiological stress that results from their disruption. Thus, we took advantage of a cold-blooded teleost fish that… Continue reading Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Category: Infectivology
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Highlights •Circulating monocytes migrate to the bone marrow upon fasting•Monocytes augment CXCR4 via a fasting-induced hormonal stress response•Re-feeding after prolonged fasting results in a surge of monocytes into circulation•Prolonged fasting and re-feeding alter the immune response to bacterial infection SummaryDiet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and… Continue reading Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report
A 71-year-old man was transferred urgently to our hospital after collapsing near his home post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, Comirnaty®). Immediately after arrival at our hospital, cardiac arrest due to complete atrioventricular block with no ventricular escaped beats was observed on electrocardiogram. Echocardiography showed preserved left ventricular ejection… Continue reading Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report
Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
IntroductionRecent evidence suggests that oxidative stress and endothelial dysfunction play critical roles in the pathophysiology of COVID-19 and Long-COVID. We hypothesized that a supplementation combining L-Arginine (to improve endothelial function) and Vitamin C (to reduce oxidation) could have favorable effects on Long-COVID symptoms.MethodsWe designed a survey (LINCOLN: L-Arginine and Vitamin C improves Long-COVID), assessing several symptoms that have been associated with Long-COVID to be administered… Continue reading Combining L-Arginine with vitamin C improves long-COVID symptoms: The LINCOLN Survey
Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population
The coronavirus disease 2019 (COVID-19) has been a challenge for the whole world since the beginning of 2020, and COVID-19 vaccines were considered crucial for disease eradication. Instead of producing classic vaccines, some companies pointed to develop products that mainly function by inducing, into the host, the production of the antigenic protein of SARS-CoV-2 called… Continue reading Safety of COVID-19 Vaccines in Patients with Autoimmune Diseases, in Patients with Cardiac Issues, and in the Healthy Population
Physical interventions to interrupt or reduce the spread of respiratory viruses
...We included 11 new RCTs and cluster‐RCTs (610,872 participants) in this update, bringing the total number of RCTs to 78. Six of the new trials were conducted during the COVID‐19 pandemic; two from Mexico, and one each from Denmark, Bangladesh, England, and Norway. We identified four ongoing studies, of which one is completed, but unreported, evaluating masks… Continue reading Physical interventions to interrupt or reduce the spread of respiratory viruses
Mask mandate and use efficacy for COVID-19 containment in US States
Background: COVID-19 pandemic mitigation requires evidence-based strategies. Because COVID-19 can spread via respired droplets, most US states mandated mask use in public settings. Randomized control trials have not clearly demonstrated mask efficacy against respiratory viruses, and observational studies conflict on whether mask use predicts lower infection rates. We hypothesized that statewide mask mandates and mask… Continue reading Mask mandate and use efficacy for COVID-19 containment in US States
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
BACKGROUND:Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.METHODS:From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General… Continue reading Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
BACKGROUND:Cases of adolescents and young adults developing myocarditis after vaccination with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–targeted mRNA vaccines have been reported globally, but the underlying immunoprofiles of these individuals have not been described in detail.METHODS:From January 2021 through February 2022, we prospectively collected blood from 16 patients who were hospitalized at Massachusetts General… Continue reading Circulating Spike Protein Detected in Post–COVID-19 mRNA Vaccine Myocarditis
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