SARS-CoV2 host cell infection is mediated by the binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/Ang1-7/Mas axis downregulation, increased ACE2 activity was shown to mediate disease protection. Since angiotensin II receptor blockers (ARBs), ACE inhibitors, and mineralocorticoid receptor antagonists (MRAs) increase ACE2 receptor expression,… Continue reading Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System
Category: Infectivology
#Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome #coronavirus 2 with high potency
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of the investigational nucleotide analogue remdesivir (RDV). RDV shows broad-spectrum antiviral activity against RNA viruses,… Continue reading #Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome #coronavirus 2 with high potency
#Coronavirus membrane fusion mechanism offers as a potential target for antiviral development
The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to develop effective therapies against the causative agent, SARS-CoV-2, and also against other pathogenic coronaviruses (CoV) that have emerged in the past or might appear in future. Researchers are therefore focusing on steps in the CoV replication cycle that may be vulnerable to… Continue reading #Coronavirus membrane fusion mechanism offers as a potential target for antiviral development
Effectiveness of Surgical and Cotton #Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients
..Neither surgical nor cotton masks effectively filtered SARS–CoV-2 during coughs by infected patients. Prior evidence that surgical masks effectively filtered influenza virus (1) informed recommendations that patients with confirmed or suspected COVID-19 should wear face masks to prevent transmission (2). However, the size and concentrations of SARS–CoV-2 in aerosols generated during coughing are unknown. Oberg… Continue reading Effectiveness of Surgical and Cotton #Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients
Early Transmission Dynamics in Wuhan, China, of Novel #Coronavirus–Infected Pneumonia
The initial cases of novel coronavirus (2019-nCoV)–infected pneumonia (NCIP) occurred in Wuhan, Hubei Province, China, in December 2019 and January 2020. We analyzed data on the first 425 confirmed cases in Wuhan to determine the epidemiologic characteristics of NCIP.. ..Among the first 425 patients with confirmed NCIP, the median age was 59 years and 56%… Continue reading Early Transmission Dynamics in Wuhan, China, of Novel #Coronavirus–Infected Pneumonia
Respiratory virus shedding in exhaled breath and efficacy of face #masks
We identified seasonal human coronaviruses, influenza viruses and rhinoviruses in exhaled breath and coughs of children and adults with acute respiratory illness. Surgical face masks significantly reduced detection of influenza virus RNA in respiratory droplets and coronavirus RNA in aerosols, with a trend toward reduced detection of coronavirus RNA in respiratory droplets. Our results indicate… Continue reading Respiratory virus shedding in exhaled breath and efficacy of face #masks
Evolving Epidemiology and Impact of Non-pharmaceutical Interventions on the Outbreak of #Coronavirus Disease 2019 in Wuhan, China
..The median age of the cases was 57 years and 50.3% were women. The attack rate peaked in the third period and substantially declined afterwards across geographic regions, sex and age groups, except for children (age <20) whose attack rate continued to increase. Healthcare workers and elderly people had higher attack rates and severity risk… Continue reading Evolving Epidemiology and Impact of Non-pharmaceutical Interventions on the Outbreak of #Coronavirus Disease 2019 in Wuhan, China
A high-#salt diet compromises antibacterial neutrophil responses through hormonal perturbation
The Western diet is rich in salt, which poses various health risks. A high-salt diet (HSD) can stimulate immunity through the nuclear factor of activated T cells 5 (Nfat5)–signaling pathway, especially in the skin, where sodium is stored. The kidney medulla also accumulates sodium to build an osmotic gradient for water conservation. Here, we studied… Continue reading A high-#salt diet compromises antibacterial neutrophil responses through hormonal perturbation
Seasonality of Respiratory Viral Infections
The seasonal cycle of respiratory viral diseases has been widely recognized for thousands of years, as annual epidemics of the common cold and influenza disease hit the human population like clockwork in the winter season in temperate regions. Moreover, epidemics caused by viruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and the newly emerging… Continue reading Seasonality of Respiratory Viral Infections
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