We have applied mathematical modeling to investigate the infections of the ongoing COVID‐19 pandemic caused by SARS‐CoV‐2 virus. We first validated our model using the well‐studied influenza viruses and then compared the pathogenesis processes between the two viruses. The interaction between host innate and adaptive immune responses was found to be a potential cause for… Continue reading Mathematical Modeling of Interaction between Innate and Adaptive #Immune Responses in #COVID‐19 and Implications for Viral Pathogenesis
Category: Infectivology
Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks
The emergence of a pandemic affecting the respiratory system can result in a significant demand for face masks. This includes the use of cloth masks by large sections of the public, as can be seen during the current global spread of COVID-19. However, there is limited knowledge available on the performance of various commonly available… Continue reading Aerosol Filtration Efficiency of Common Fabrics Used in Respiratory Cloth Masks
#COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?
Since the declaration of COVID-19 pandemic infection by the World Health Organization, many governmental restrictions have been differently applied in the involved countries in order to contain the spread of the infection; Italy applied severe restrictive, public measures actually confining the entire population to an almost complete lockdown for several weeks; the restrictive quarantine can… Continue reading #COVID-19: the critical balance between appropriate governmental restrictions and expected economic, psychological and social consequences in Italy. Are we going in the right direction?
#Coronavirus: Lockdown’s heavy toll on Italy’s mental health
Italy’s coronavirus death toll is the second highest in the world, and its lockdown is the strictest and longest in Europe. Doctors say both things are creating a mental health emergency. The BBC has been given access to a psychological support centre run by the Red Cross, where staff say they’re overwhelmed by calls from… Continue reading #Coronavirus: Lockdown’s heavy toll on Italy’s mental health
Multicenter initial guidance on use of antivirals for children with #COVID-19/SARS-CoV-2
Although Coronavirus Disease 2019 (COVID-19) is mild in nearly all children, a small proportion of pediatric patients develops severe or critical illness. Guidance is therefore needed regarding use of agents with potential activity against severe acute respiratory syndrome coronavirus 2 in pediatrics.. ..Given the typically mild course of pediatric COVID-19, supportive care alone is suggested… Continue reading Multicenter initial guidance on use of antivirals for children with #COVID-19/SARS-CoV-2
#ST-Segment Elevation in Patients with #Covid-19 — A Case Series
Myocardial injury with ST-segment elevation has been observed in patients with coronavirus disease 2019 (Covid-19). Here, we describe our experience in the initial month of the Covid-19 outbreak in New York City. Patients with confirmed Covid-19 who had ST-segment elevation on electrocardiography were included in the study from six New York hospitals. Patients with Covid-19… Continue reading #ST-Segment Elevation in Patients with #Covid-19 — A Case Series
Can atmospheric #pollution be considered a co-factor in extremely high level of SARS-#CoV-2 lethality in Northern Italy?
This paper investigates the correlation between the high level of Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) lethality and the atmospheric pollution in Northern Italy. Indeed, Lombardy and Emilia Romagna are Italian regions with both the highest level of virus lethality in the world and one of Europe’s most polluted area. Based on this correlation,… Continue reading Can atmospheric #pollution be considered a co-factor in extremely high level of SARS-#CoV-2 lethality in Northern Italy?
Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System
SARS-CoV2 host cell infection is mediated by the binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation observed in SARS-CoV was previously postulated to be due to ACE2/Ang1-7/Mas axis downregulation, increased ACE2 activity was shown to mediate disease protection. Since angiotensin II receptor blockers (ARBs), ACE inhibitors, and mineralocorticoid receptor antagonists (MRAs) increase ACE2 receptor expression,… Continue reading Clinical Implications of SARS-Cov2 Interaction with Renin #Angiotensin System
#Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome #coronavirus 2 with high potency
Effective treatments for coronavirus disease 2019 (COVID-19) are urgently needed to control this current pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Replication of SARS-CoV-2 depends on the viral RNA-dependent RNA polymerase (RdRp), which is the likely target of the investigational nucleotide analogue remdesivir (RDV). RDV shows broad-spectrum antiviral activity against RNA viruses,… Continue reading #Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome #coronavirus 2 with high potency
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