The proportion of asymptomatic carriers and transmission risk factors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among household and non-household contacts remains unclear. In Singapore, extensive contact tracing by the Ministry of Health for every diagnosed COVID-19 case, and legally enforced quarantine and intensive health surveillance of close contacts provided a rare opportunity to… Continue reading #SARS-CoV-2 seroprevalence and #transmission risk factors among high-risk close contacts: a retrospective cohort study
Category: Infectivology
#Prothrombotic autoantibodies in serum from patients hospitalized with #COVID-19
Patients with COVID-19 are at high risk for thrombotic arterial and venous occlusions. Lung histopathology often reveals fibrin-based occlusions in the small blood vessels of patients who succumb to the disease. Antiphospholipid syndrome is an acquired and potentially life-threatening thrombophilia in which patients develop pathogenic autoantibodies targeting phospholipids and phospholipid-binding proteins (aPL antibodies). Case series… Continue reading #Prothrombotic autoantibodies in serum from patients hospitalized with #COVID-19
GES: A validated simple score to predict the risk of #HCC in patients with #HCV‐GT4‐associated advanced liver fibrosis after oral antivirals
Hepatocellular carcinoma (HCC) risk persists after hepatitis C virus (HCV) eradication with direct‐acting antivirals (DAAs), particularly in patients with cirrhosis. Identifying those who are likely to develop HCC is a critical unmet medical need. Our aim is to develop a score that offers individualized patient HCC risk prediction.. ..In the derivation cohort, the median follow‐up… Continue reading GES: A validated simple score to predict the risk of #HCC in patients with #HCV‐GT4‐associated advanced liver fibrosis after oral antivirals
Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data
Housing characteristics and neighbourhood context are considered risk factors for COVID-19 mortality among older adults. The aim of this study was to investigate how individual-level housing and neighbourhood characteristics are associated with COVID-19 mortality in older adults.. ..Of 279 961 individuals identified to be aged 70 years or older on March 12, 2020, and residing in… Continue reading Residential context and #COVID-19 mortality among adults aged 70 years and older in Stockholm: a population-based, observational study using individual-level data
Sex, age, and hospitalization drive #antibody responses in a #COVID-19 convalescent plasma donor population
Convalescent plasma is a leading treatment for coronavirus disease 2019 (COVID-19), but there is a paucity of data identifying its therapeutic efficacy. Among 126 potential convalescent plasma donors, the humoral immune response was evaluated using a severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) virus neutralization assay with Vero-E6-TMPRSS2 cells; a commercial IgG and IgA ELISA… Continue reading Sex, age, and hospitalization drive #antibody responses in a #COVID-19 convalescent plasma donor population
Effect of #Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With #COVID-19 Pneumonia
The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile.. ..Patients in the experimental arm received intravenous tocilizumab within 8 hours from randomization (8 mg/kg up to a maximum of 800 mg), followed by a… Continue reading Effect of #Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With #COVID-19 Pneumonia
Association of postoperative #influenza vaccine on overall mortality in patients undergoing curative surgery for solid #tumors
Recent findings have found that the influenza vaccine induces changes in the immune system in favor of anti‐tumor cytotoxicity. The aim in this study was to investigate if an influenza vaccine given in the postoperative period decreased overall and cancer‐specific mortality in patients undergoing curative surgery for solid cancers. We conducted a registry‐based national observational… Continue reading Association of postoperative #influenza vaccine on overall mortality in patients undergoing curative surgery for solid #tumors
Orthogonal SARS-#CoV-2 Serological Assays Enable Surveillance of Low Prevalence Communities and Reveal Durable Humoral Immunity
We conducted a serological study to define correlates of immunity against SARS-CoV-2. Relative to mild COVID-19 cases, individuals with severe disease exhibited elevated virus-neutralizing titers and antibodies against nucleocapsid (N) and the receptor binding domain (RBD) of spike protein. Age and sex played lesser roles. All cases, including asymptomatic individuals, seroconverted by 2 weeks post-PCR… Continue reading Orthogonal SARS-#CoV-2 Serological Assays Enable Surveillance of Low Prevalence Communities and Reveal Durable Humoral Immunity
Risk of failure in dual therapy versus triple therapy in naïve #HIV-patients: a systematic review and meta-analysis
Several attempts have been made to test different drug-sparing strategies to reduce the drug-burden and drug-related toxicities.. ..Fourteen studies were included, allowing a meta-analysis on 5,205 patients. The meta-analysis performed on studies that presented data at 48 weeks showed that the relative risk (RR) of treatment failure (TF) (RR>1 favoring triple therapy) in 10 studies… Continue reading Risk of failure in dual therapy versus triple therapy in naïve #HIV-patients: a systematic review and meta-analysis
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