Background: #Cefazolin , a first-generation #cephalosporin , is the standard antibiotic for perioperative prophylaxis in patients undergoing hip or knee arthroplasty. Research has demonstrated significantly higher periprosthetic joint infection ( #PJI ) rates when non-cefazolin antibiotics are used for prophylaxis. Notably, cefazolin contains an R1 side chain that has not shown cross-reactivity with other cephalosporins.… Continue reading Cefazolin and the R1 Side Chain: Why Patients with a Cephalosporin Allergy Can Be Safely Given Cefazolin While Undergoing Joint Arthroplasty
Category: Infectivology
Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Purpose: Data on the reliability of point-of-care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) #D-dimer (DD), interleukin 6 (IL-6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL-6 and PCT in comparison… Continue reading Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
Background: #D-dimer has gained considerable attention since its inclusion as a minor criterion in the 2018 International Consensus Meeting. However, evidence regarding its diagnostic accuracy for periprosthetic joint infection ( #PJI ) remains inconclusive. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of D-dimer in diagnosing PJI and comprehensively explore the sources… Continue reading Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
#Knee flexion during skin preparation improves anterior #antiseptic coverage: A controlled fluorescent dye study
AbstractBackground: Periprosthetic joint infection ( #PJI ) is a rare but devastating complication of total knee arthroplasty (TKA) and a leading cause of TKA failure. Thorough skin preparation is a key preventative measure; however, the influence of limb position on antiseptic coverage has not been evaluated. This study compared the effectiveness of anterior knee antiseptic… Continue reading #Knee flexion during skin preparation improves anterior #antiseptic coverage: A controlled fluorescent dye study
Comparison of verbal autopsy using a large #language model to biologically confirmed causes of death for #malaria and other communicable diseases among children in six sub-Saharan African countries
Malaria, a preventable parasitic disease, causes most child deaths in sub-Saharan Africa (SSA). Reliable cause-of-death data are essential to evaluate progress toward the national and global malaria control goals. However, civil registration and vital statistics are often weak and incomplete in many low- and middle-income countries. In such circumstances, verbal autopsy (VA) provides an alternative… Continue reading Comparison of verbal autopsy using a large #language model to biologically confirmed causes of death for #malaria and other communicable diseases among children in six sub-Saharan African countries
The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute #periprosthetic joint infection
Background: Acute periprosthetic joint infection (#PJI ) is a serious complication after total knee and hip replacement, with varying success rates in its management using debridement, antibiotics, and implant retention (DAIR). We hypothesize that the application of post-operative continuous negative pressure therapy (CNPT) can improve the success rate of DAIR in the treatment of acute… Continue reading The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute #periprosthetic joint infection
Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections
Staphylococcus aureus small-colony variants (SCVs) are unique phenotypic forms that significantly contribute to the development of chronic, recurrent, and treatment-refractory infections. These variants arise from metabolic defects, most commonly in the menadione, hemin, or thymidine biosynthetic pathways, leading to slow growth, atypical colony morphology, and altered virulence expression. The ability of these bacteria to persist… Continue reading Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections
Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis, particularly in young males and typically after the second dose, have been observed. Here, we explore the mediators of this myocarditis to better understand and to enhance the safety of future mRNA… Continue reading Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
Early shift to oral #antibiotic treatment for pyogenic vertebral #osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial
BackgroundThe current Danish National Guideline (DNG) for treatment of pyogenic vertebral osteomyelitis (PVO) recommends 6 weeks antibiotic (AB) treatment, with a 2-week intravenous (IV) AB lead-in followed by 4 weeks oral AB for uncomplicated PVO, and 12 weeks AB treatment with a 4-week IV AB lead-in followed by 8 weeks oral AB for complicated PVO.The… Continue reading Early shift to oral #antibiotic treatment for pyogenic vertebral #osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial
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