AbstractBackground: Periprosthetic joint infection ( #PJI ) is a rare but devastating complication of total knee arthroplasty (TKA) and a leading cause of TKA failure. Thorough skin preparation is a key preventative measure; however, the influence of limb position on antiseptic coverage has not been evaluated. This study compared the effectiveness of anterior knee antiseptic… Continue reading #Knee flexion during skin preparation improves anterior #antiseptic coverage: A controlled fluorescent dye study
Category: Infectivology
Comparison of verbal autopsy using a large #language model to biologically confirmed causes of death for #malaria and other communicable diseases among children in six sub-Saharan African countries
Malaria, a preventable parasitic disease, causes most child deaths in sub-Saharan Africa (SSA). Reliable cause-of-death data are essential to evaluate progress toward the national and global malaria control goals. However, civil registration and vital statistics are often weak and incomplete in many low- and middle-income countries. In such circumstances, verbal autopsy (VA) provides an alternative… Continue reading Comparison of verbal autopsy using a large #language model to biologically confirmed causes of death for #malaria and other communicable diseases among children in six sub-Saharan African countries
The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute #periprosthetic joint infection
Background: Acute periprosthetic joint infection (#PJI ) is a serious complication after total knee and hip replacement, with varying success rates in its management using debridement, antibiotics, and implant retention (DAIR). We hypothesize that the application of post-operative continuous negative pressure therapy (CNPT) can improve the success rate of DAIR in the treatment of acute… Continue reading The effect of post-operative continuous negative pressure therapy after debridement, antibiotics, and implant retention for acute #periprosthetic joint infection
Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections
Staphylococcus aureus small-colony variants (SCVs) are unique phenotypic forms that significantly contribute to the development of chronic, recurrent, and treatment-refractory infections. These variants arise from metabolic defects, most commonly in the menadione, hemin, or thymidine biosynthetic pathways, leading to slow growth, atypical colony morphology, and altered virulence expression. The ability of these bacteria to persist… Continue reading Small-colony variants of #Staphylococcus aureus: hidden threat in chronic and recurrent #infections
Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
Messenger RNA (mRNA) vaccines against SARS-CoV-2 are highly effective and were instrumental in curbing the COVID-19 pandemic. However, rare cases of noninfective myocarditis, particularly in young males and typically after the second dose, have been observed. Here, we explore the mediators of this myocarditis to better understand and to enhance the safety of future mRNA… Continue reading Inhibition of CXCL10 and IFN-γ ameliorates #myocarditis in preclinical models of SARS-CoV-2 #mRNA vaccination
Early shift to oral #antibiotic treatment for pyogenic vertebral #osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial
BackgroundThe current Danish National Guideline (DNG) for treatment of pyogenic vertebral osteomyelitis (PVO) recommends 6 weeks antibiotic (AB) treatment, with a 2-week intravenous (IV) AB lead-in followed by 4 weeks oral AB for uncomplicated PVO, and 12 weeks AB treatment with a 4-week IV AB lead-in followed by 8 weeks oral AB for complicated PVO.The… Continue reading Early shift to oral #antibiotic treatment for pyogenic vertebral #osteomyelitis (SAVE): study protocol for an open label, non-inferiority, nation-wide randomized controlled clinical trial
Discovery of Late Intermediates in #Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive #Bacterial Pathogens
The methylenomycins are highly functionalized cyclopentanone antibiotics produced by Streptomyces coelicolor A3(2). A biosynthetic pathway to the methylenomycins has been proposed based on sequence analysis of the proteins encoded by the methylenomycin biosynthetic gene cluster and the incorporation of labeled precursors. However, the roles played by putative biosynthetic enzymes remain experimentally uninvestigated. Here, the biosynthetic… Continue reading Discovery of Late Intermediates in #Methylenomycin Biosynthesis Active against Drug-Resistant Gram-Positive #Bacterial Pathogens
Monoclonal #antibodies protect against pandrug-resistant #Klebsiella pneumoniae
The ‘silent pandemic’ caused by antimicrobial resistance requires innovative therapeutic approaches. Human monoclonal antibodies (mAbs), which are among the most transformative and safe drugs in oncology1 and autoimmunity2, are rarely used for infectious diseases and not yet used for antimicrobial resistance3. Here we applied an antigen-agnostic strategy to isolate extremely potent human mAbs against Klebsiella… Continue reading Monoclonal #antibodies protect against pandrug-resistant #Klebsiella pneumoniae
Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
BackgroundA subgroup analysis of the COVID-OUT trial's long-term outcome found that starting metformin within 3 days of coronavirus disease 2019 (COVID-19) diagnosis reduced post–COVID-19 condition (PCC) incidence by 63% in overweight or obese individuals. However, its generalizability remains uncertain.ObjectivesTo evaluate the effectiveness of metformin in preventing PCC in adults with overweight or obesity who had… Continue reading Effect of #Metformin on the Risk of Post- #coronavirus Disease 2019 Condition Among Individuals With #Overweight or #Obese: A Population-based Retrospective Cohort Study
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