Objectives: To observe the effect of electroacupuncture (EA) at "Sanyinjiao" (SP6) and "Zusanli" (ST36) on the expressions of peroxisome proliferator-activated γ receptor (PPAR-γ), nuclear factor-κB (NF-κB) and glucose transporter 4 (GLUT4) in skeletal muscle of Zucker Diabetic Fatty (ZDF) rats with type 2 diabetes mellitus (T2DM), so as to explore its possible mechanism in improving… Continue reading #Electroacupuncture ameliorates skeletal muscle #insulin resistance in #diabetic rats via PPAR-γ/NF-κB signaling pathway
Category: Endocrinology
Improving non-invasive #glucose estimation with monthly calibrated #photoplethysmography and implicit #HbA1c
Background: Most noninvasive blood glucose technologies, especially wearable photoplethysmography devices, require multiple calibrations and are often limited to narrow cohorts such as unmedicated or mild cases. We assess whether a single pretest once per month can meet clinical accuracy while broadening applicability through cohort-specific models.Methods: We develop models for three groups: (i) individuals not using… Continue reading Improving non-invasive #glucose estimation with monthly calibrated #photoplethysmography and implicit #HbA1c
Effect of Sodium-Glucose Co-transporter 2 ( #SGLT2 ) Inhibitors in the Management of #Hyponatremia Associated With Syndrome of Inappropriate Antidiuresis
AbstractBackground: Hyponatremia due to syndrome of inappropriate antidiuresis (SIAD) is a common and challenging electrolyte disorder, particularly in hospitalized and elderly patients. Conventional treatments, such as fluid restriction and vasopressin receptor antagonists, have limitations related to efficacy, tolerance, availability, and cost. Sodium-glucose co-transporter 2 inhibitors (SGLT2i), primarily used for type 2 diabetes, have shown potential… Continue reading Effect of Sodium-Glucose Co-transporter 2 ( #SGLT2 ) Inhibitors in the Management of #Hyponatremia Associated With Syndrome of Inappropriate Antidiuresis
Dual target, dual benefit: real-world effects of #SGLT2 inhibitors and #GLP-1 receptor agonists on the FIB-4 score in people with type 2 #diabetes mellitus
Liver fibrosis is a serious comorbidity of type 2 diabetes mellitus (T2DM) in which non-invasive indices such as FIB-4 are used to monitor hepatic health. This study assesses the impact of GLP-1 receptor agonists (GLP-1RA), SGLT2 inhibitors (SGLT2i), and their combinations on FIB-4 scores in people with T2DM.MethodsWe conducted a retrospective analysis of 133 adults… Continue reading Dual target, dual benefit: real-world effects of #SGLT2 inhibitors and #GLP-1 receptor agonists on the FIB-4 score in people with type 2 #diabetes mellitus
#Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
This study aimed to determine if sodium-glucose co-transporter-2 inhibitors (SGLT2i) use in diabetic patients leads to erythrocytosis and increases the incidence of arterial and venous thrombosis events. This is a retrospective cohort study using records from over 50 U.S. healthcare organizations. Adults with type 2 diabetes who received SGLT2i therapy were compared to those on… Continue reading #Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Chronic kidney disease (CKD) is a devastating progressive condition accompanied with high morbidity and mortality rates. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have recently proven their renoprotective effects, whereas evidence for metformin remains limited but suggestive of potential benefit. This study aimed at comparing the efficacy and safety of metformin versus empagliflozin, a SGLT2 inhibitor, on retarding… Continue reading Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
The effects of glucagon-like peptide-1 receptor agonists (#GLP1-RAs ) on #alcohol -related outcomes: a systematic review and meta-analysis
Objective: To evaluate the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on alcohol-related outcomes in adults with or without alcohol use disorder (AUD).Methods: A systematic review and meta-analysis following PRISMA guidelines searched PubMed, Embase, and Cochrane Library up to May 3, 2025. Eligible studies included randomized controlled trials (RCTs) and observational studies assessing GLP-1RAs (e.g.,… Continue reading The effects of glucagon-like peptide-1 receptor agonists (#GLP1-RAs ) on #alcohol -related outcomes: a systematic review and meta-analysis
Effects of #finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 #diabetes and chronic #kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
Background: The mechanisms underlying cardiorenal benefits of finerenone remain unclear. This mechanistic trial aimed to evaluate the effects of finerenone on vascular stiffness, as assessed using the cardio-ankle vascular index (CAVI), and cardiorenal biomarkers in patients with type 2 diabetes (T2D) and chronic kidney disease (CKD).Methods: Eligible patients with T2D and CKD (estimated glomerular filtration… Continue reading Effects of #finerenone on arterial stiffness and cardiorenal biomarkers in patients with type 2 #diabetes and chronic #kidney disease: a randomised placebo-controlled mechanistic trial (FIVE-STAR)
Transition between #prediabetic and #diabetic stages in an urban community in india: a decade-long retrospective cohort study
The rising prevalence of prediabetes has increased the risk of diabetes, particularly among younger populations, if timely interventions are not implemented. In India, the limited availability of cohort-based incidence studies underscores the need for retrospective analyses using hospital-based electronic medical information systems (EMIS). This study estimates the transition probabilities and duration of stay in the… Continue reading Transition between #prediabetic and #diabetic stages in an urban community in india: a decade-long retrospective cohort study
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