Key messagesEczema is commonly colonized by Staphylococcus aureus so some advocate antibiotics or dilute bleach baths. This Cochrane review evaluated trials of anti-staph treatments in people with infected or uninfected eczema. From 41 trials (1753 participants), there was little evidence that these interventions impact eczema symptoms. ... 2.7 Authors’ conclusionsWe found insufficient evidence on the… Continue reading How effective are interventions to reduce Staphylococcus aureus in eczema?
Category: Dermatology
Ketoconazole 2% Cream Alters the Skin Fungal Microbiome in Seborrheic Dermatitis: a Cohort Study
Seborrheic dermatitis (SD) is a common chronic inflammatory dermatosis. Current theories highlight the role of microbes on the skin surface in the pathogenesis of SD. Ketoconazole is commonly used for the treatment of SD. However, there remains limited data focusing on the effects of ketoconazole on shaping the skin microbiome in patients with SD. ObjectiveIn… Continue reading Ketoconazole 2% Cream Alters the Skin Fungal Microbiome in Seborrheic Dermatitis: a Cohort Study
Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
Janus kinase (JAK) inhibitors have shown encouraging results in the treatment of alopecia areata (AA), an autoimmune form of hair loss, in small, uncontrolled studies and case reports. ObjectiveWe conducted a biopsy substudy during the randomized, double-blind, placebo-controlled first 24 weeks of a phase 2a clinical trial that evaluated the efficacy and safety of ritlecitinib,… Continue reading Ritlecitinib and brepocitinib demonstrate significant improvement in scalp alopecia areata biomarkers
Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate-to-severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase III, long-term studies
Interleukin (IL)-31 affects the inflammatory response, is involved in epidermal barrier disruption in atopic dermatitis (AD) and plays a key role in pruritus. Nemolizumab, a humanized monoclonal antibody against IL-31 receptor A, reduced pruritus in patients with AD after a 16-week administration period. ObjectivesTo examine the long-term effectiveness and safety of nemolizumab in patients aged… Continue reading Nemolizumab plus topical agents in patients with atopic dermatitis (AD) and moderate-to-severe pruritus provide improvement in pruritus and signs of AD for up to 68 weeks: results from two phase III, long-term studies
Role of nutritional supplements in selected dermatological disorders: A review
While a plethora of literature continues to be published on the role of nutritional agents both in lay press and indexed journals, the data is not on a firm footing and leaves the dermatologist in a quandry and the patient confused. The various agents include vitamins, minerals, amino acids, antioxidants, diets & gluten. A proper… Continue reading Role of nutritional supplements in selected dermatological disorders: A review
Trial of Spesolimab for Generalized Pustular Psoriasis
Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 signaling is involved in the pathogenesis of this disorder. Spesolimab, a humanized anti–interleukin-36 receptor monoclonal antibody, is being studied for the treatment of GPP flares. In a phase 2 trial, we randomly assigned patients with a… Continue reading Trial of Spesolimab for Generalized Pustular Psoriasis
Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
During aging of human skin, a number of intrinsic and extrinsic factors cause the alteration of the skin’s structure, function and cutaneous physiology. Many studies have investigated the influence of the skin microbiome on these alterations, but the molecular mechanisms that dictate the interplay between these factors and the skin microbiome are still not fully… Continue reading Charting host-microbe co-metabolism in #skin #aging and application to metagenomics data
Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Are melanomas diagnosed through routine skin checks (a proxy for skin cancer screening) associated with reduced melanoma-specific and all-cause mortality? Findings This population-based cohort study included 2452 patients, each with 1 diagnosed melanoma, 35% of which were detected during a routine skin check. In multivariable analyses, routine skin-check detection was associated with a subhazard ratio… Continue reading Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Prevalence and Associated Diseases of #Seborrheic Skin in Adults
Seborrhea is a skin condition characterized by abundant production of sebum associated with typical dermatological conditions such as rosacea and acne. Little is known about the prevalence of seborrhea and the frequency of concurrent skin diseases in the general population. Objective: To investigate the epidemiology and comorbidity of seborrhea in the adolescent and adult working… Continue reading Prevalence and Associated Diseases of #Seborrheic Skin in Adults
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