Colon cancer (CC) is the third most diagnosed malignancy and second leading cause of cancer mortality globally, with ~ 1.9 million new cases and 903,859 deaths annually (Bray et al. in CA Cancer J Clin 68(6):394–424, 2018). Diet represents a key modifiable risk factor for CC pathogenesis (Herr and Buchler in Cancer Treat Rev 36:377–383, 2010). Cruciferous… Continue reading #Cruciferous #vegetables intake and risk of #colon #cancer: a dose–response meta-analysis
Tag: colorectal
#Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal #cancer
Diet, microbiome, inflammation and host genetics have been linked to colorectal cancer development; however, it is not clear whether and how these factors interact to promote carcinogenesis. Here we used Il10−/− mice colonized with bacteria previously associated with colorectal cancer: enterotoxigenic Bacteroides fragilis, Helicobacter hepaticus or colibactin-producing (polyketide synthase-positive (pks+)) Escherichia coli and fed either… Continue reading #Dietary fibre counters the oncogenic potential of colibactin-producing Escherichia coli in colorectal #cancer
Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains Bifidobacterium. We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgroups according to the amount of tissue Bifidobacterium. We utilized the prospective cohort incident-tumor biobank method and resources of two prospective cohort studies. Inverse probability… Continue reading Long-term #yogurt intake and colorectal #cancer incidence subclassified by Bifidobacterium abundance in tumor
Defining ortholog-specific UHRF1 inhibition by STELLA for #cancer therapy
UHRF1 maintains DNA methylation by recruiting DNA methyltransferases to chromatin. In mouse, these dynamics are potently antagonized by a natural UHRF1 inhibitory protein STELLA, while the comparable effects of its human ortholog are insufficiently characterized, especially in cancer cells. Herein, we demonstrate that human STELLA (hSTELLA) is inadequate, while mouse STELLA (mSTELLA) is fully proficient… Continue reading Defining ortholog-specific UHRF1 inhibition by STELLA for #cancer therapy
#Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Importance Aspirin reduces the risk of colorectal cancer (CRC). Identifying individuals more likely to benefit from regular aspirin use for CRC prevention is a high priority.Objective To assess whether aspirin use is associated with the risk of CRC across different lifestyle risk factors.Design, Setting, and Participants A prospective cohort study among women in the Nurses’ Health Study (1980-2018)… Continue reading #Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
AbstractBackgroundUse of multivitamin supplements has been associated with lower incidence of colorectal cancer (CRC). However, its influence on CRC survival remains unknown.MethodsAmong 2424 patients with stage I–III CRC who provided detailed information about multivitamin supplements in the Nurses’ Health Study and Health Professionals Follow-up Study, the authors calculated multivariable hazard ratios (HRs) of multivitamin supplements… Continue reading Post-diagnostic #multivitamin supplement use and #colorectal cancer survival: A prospective cohort study
Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, and challenging endoscopic resection make the identification of their metabolic requirements a priority. Here, we demonstrate… Continue reading Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Hepatobiliary cancers share risk factors with colorectal cancer (CRC), but there are no combined screening programs for these conditions.AimsThe aim of this study was to assess whether patients with high-risk colonic polyps are more likely to die from liver related tumors than patients with a negative colonoscopy.MethodsIn this retrospective analysis of mortality data, Austrian screening… Continue reading Detection of high-risk #polyps at screening colonoscopy indicates risk for #liver and #biliary #cancer death
Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement From the American College of Physicians (Version 2)
The purpose of this updated guidance statement is to guide clinicians on screening for colorectal cancer (CRC) in asymptomatic average-risk adults. The intended audience is all clinicians. The population is asymptomatic adults at average risk for CRC.Methods:This updated guidance statement was developed using recently published and critically appraised clinical guidelines from national guideline developers since… Continue reading Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement From the American College of Physicians (Version 2)
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