Dysregulation of the gut microbiome has been implicated in Parkinson's disease (PD). This study aimed to evaluate the clinical effects and safety of a single faecal microbiota transplantation (FMT) in patients with early-stage PD.MethodsThe GUT-PARFECT trial, a single-centre randomised, double-blind, placebo-controlled trial was conducted at Ghent University Hospital between December 01, 2020 and December 12,… Continue reading Safety and efficacy of faecal #microbiota transplantation in patients with mild to moderate #Parkinson’s disease (GUT-PARFECT): a double-blind, placebo-controlled, randomised, phase 2 trial
Tag: Parkinson
NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To evaluate the safety of high-dose NR therapy, we conducted a single-center, randomized, placebo-controlled, double-blind,… Continue reading NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal #Parkinson’s disease
•α-syn32-46 immunization of HLA-DRB1∗15:01 mice triggers weight loss and constipation•α-syn32-46 immunizations induce inflammation and neuron loss in the gut•Depletion of CD4+, but not CD8+, T cells partially rescues enteric neural loss•Both α-syn32-46 and HLA-DRB1∗15:01 are critical for this model of prodromal PD SummaryEnteric symptoms are hallmarks of prodromal Parkinson’s disease (PD) that appear decades before the onset of motor… Continue reading Interaction of an α-synuclein epitope with HLA-DRB1∗15:01 triggers enteric features in mice reminiscent of prodromal #Parkinson’s disease
American #Football Play and #Parkinson Disease Among Men
Importance Parkinsonism and Parkinson disease (PD) are known to result from repetitive head impacts from boxing. Repetitive head impacts from American football may also be associated with increased risk of neurodegenerative pathologies that cause parkinsonism, yet in vivo research on the association between football play and PD is scarce and limited by small samples and equivocal… Continue reading American #Football Play and #Parkinson Disease Among Men
Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis
Parkinson’s disease is a progressive neurodegenerative movement disorder with a long latent phase and currently no disease-modifying treatments. Reliable predictive biomarkers that could transform efforts to develop neuroprotective treatments remain to be identified. Using UK Biobank, we investigated the predictive value of accelerometry in identifying prodromal Parkinson’s disease in the general population and compared this… Continue reading Wearable movement-tracking data identify Parkinson’s disease years before clinical diagnosis
Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson’s disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions… Continue reading Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
Trichloroethylene: An Invisible Cause of Parkinson’s Disease?
The etiologies of Parkinson’s disease (PD) remain unclear. Some, such as certain genetic mutations and head trauma, are widely known or easily identified. However, these causes or risk factors do not account for the majority of cases. Other, less visible factors must be at play. Among these is a widely used industrial solvent and common… Continue reading Trichloroethylene: An Invisible Cause of Parkinson’s Disease?
Physical exercise for people with Parkinson’s disease: a systematic review and network meta‐analysis
Physical exercise is effective in managing Parkinson's disease (PD), but the relative benefit of different exercise types remains unclear.ObjectivesTo compare the effects of different types of physical exercise in adults with PD on the severity of motor signs, quality of life (QoL), and the occurrence of adverse events, and to generate a clinically meaningful treatment… Continue reading Physical exercise for people with Parkinson’s disease: a systematic review and network meta‐analysis
Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
Misfolded and aggregated α-synuclein is a neuropathological hallmark of Parkinson’s disease (PD). Thus, α-synuclein aggregates are regarded as a biomarker for the development of diagnostic assays. Quantification of α-synuclein aggregates in body fluids is challenging, and requires highly sensitive and specific assays. Recent studies suggest that α-synuclein aggregates may be shed into stool. We used… Continue reading Patients with isolated REM-sleep behavior disorder have elevated levels of alpha-synuclein aggregates in stool
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