Organismal aging has been associated with diverse metabolic and functional changes across tissues. Within the immune system, key features of physiological hematopoietic cell aging include increased fat deposition in the bone marrow, impaired hematopoietic stem and progenitor cell (HSPC) function, and a propensity towards myeloid differentiation. This shift in lineage bias can lead to pre-malignant… Continue reading Systemic deficits in lipid homeostasis promote aging-associated impairments in #B cell progenitor development
Tag: immune-system
Immune and metabolic effects of African heritage #diets versus Western diets in men: a randomized controlled trial
African heritage diets are increasingly being replaced by Western-style dietary patterns because of urbanization, economic development, increased access to processed foods, globalization and changing social norms. The health consequences of this nutrition transition are not well understood. We conducted a randomized controlled trial in the Kilimanjaro region in Northern Tanzania to investigate the immune and… Continue reading Immune and metabolic effects of African heritage #diets versus Western diets in men: a randomized controlled trial
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Highlights •Circulating monocytes migrate to the bone marrow upon fasting•Monocytes augment CXCR4 via a fasting-induced hormonal stress response•Re-feeding after prolonged fasting results in a surge of monocytes into circulation•Prolonged fasting and re-feeding alter the immune response to bacterial infection SummaryDiet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and… Continue reading Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome
Vitamin D is best known for its role in maintaining bone health and calcium homeostasis. However, it also exerts a broad range of extra-skeletal effects on cellular physiology and on the immune system. Vitamins D2 and D3 share a high degree of structural similarity. Functional equivalence in their vitamin D-dependent effects on human physiology is… Continue reading Vitamins D2 and D3 Have Overlapping But Different Effects on the Human Immune System Revealed Through Analysis of the Blood Transcriptome
Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs
The mRNA SARS-CoV-2 vaccines were brought to market in response to the widely perceived public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease had no precedent, but desperate times seemed to call for desperate measures. The mRNA vaccines utilize genetically modified mRNA encoding spike proteins. These alterations hide… Continue reading Innate Immune Suppression by SARS-CoV-2 mRNA Vaccinations: The role of G-quadruplexes, exosomes and microRNAs
Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
Several studies on the impact of yoga and meditation on mental and physical health have demonstrated beneficial effects. However, the potential molecular mechanisms and critical genes involved in this beneficial outcome have yet to be comprehensively elucidated. This study identified and characterized the transcriptional program associated with advanced meditation practice, and we bioinformatically integrated various… Continue reading Large-scale genomic study reveals robust activation of the immune system following advanced Inner Engineering meditation retreat
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