Background: Most noninvasive blood glucose technologies, especially wearable photoplethysmography devices, require multiple calibrations and are often limited to narrow cohorts such as unmedicated or mild cases. We assess whether a single pretest once per month can meet clinical accuracy while broadening applicability through cohort-specific models.Methods: We develop models for three groups: (i) individuals not using… Continue reading Improving non-invasive #glucose estimation with monthly calibrated #photoplethysmography and implicit #HbA1c
Tag: Diabetes
Dual target, dual benefit: real-world effects of #SGLT2 inhibitors and #GLP-1 receptor agonists on the FIB-4 score in people with type 2 #diabetes mellitus
Liver fibrosis is a serious comorbidity of type 2 diabetes mellitus (T2DM) in which non-invasive indices such as FIB-4 are used to monitor hepatic health. This study assesses the impact of GLP-1 receptor agonists (GLP-1RA), SGLT2 inhibitors (SGLT2i), and their combinations on FIB-4 scores in people with T2DM.MethodsWe conducted a retrospective analysis of 133 adults… Continue reading Dual target, dual benefit: real-world effects of #SGLT2 inhibitors and #GLP-1 receptor agonists on the FIB-4 score in people with type 2 #diabetes mellitus
#Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
This study aimed to determine if sodium-glucose co-transporter-2 inhibitors (SGLT2i) use in diabetic patients leads to erythrocytosis and increases the incidence of arterial and venous thrombosis events. This is a retrospective cohort study using records from over 50 U.S. healthcare organizations. Adults with type 2 diabetes who received SGLT2i therapy were compared to those on… Continue reading #Erythrocytosis and #thromboembolic risks associated with #SGLT2 inhibitors in type 2 diabetes
Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Chronic kidney disease (CKD) is a devastating progressive condition accompanied with high morbidity and mortality rates. Sodium-glucose cotransporter-2 (SGLT2) inhibitors have recently proven their renoprotective effects, whereas evidence for metformin remains limited but suggestive of potential benefit. This study aimed at comparing the efficacy and safety of metformin versus empagliflozin, a SGLT2 inhibitor, on retarding… Continue reading Efficacy and safety of #metformin versus #empagliflozin on chronic #kidney disease progression (MET-EMPA-CKD): a randomized controlled trial
Transition between #prediabetic and #diabetic stages in an urban community in india: a decade-long retrospective cohort study
The rising prevalence of prediabetes has increased the risk of diabetes, particularly among younger populations, if timely interventions are not implemented. In India, the limited availability of cohort-based incidence studies underscores the need for retrospective analyses using hospital-based electronic medical information systems (EMIS). This study estimates the transition probabilities and duration of stay in the… Continue reading Transition between #prediabetic and #diabetic stages in an urban community in india: a decade-long retrospective cohort study
A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
Statin therapy has been associated with increased risk of type 2 diabetes (T2D). We investigated the relationship between Low-Density Lipoprotein Cholesterol (LDL-C) plasma concentrations and incident T2D and evaluated the modifying effect of statin therapy in a large population-based cohort.MethodsIndividuals free of T2D and cardiovascular disease at baseline were followed longitudinally for the development of… Continue reading A six-year longitudinal study identifies a #statin -independent association between low LDL- #cholesterol and risk of type 2 #diabetes
#Electroacupuncture modulates myocardial insulin signaling and inflammatory markers in a rat model of type 2 #diabetes
Objective: To evaluate the effects of electroacupuncture (EA) on myocardial insulin resistance (IR) in Zucker diabetic fatty (ZDF) rats, an established model for type 2 diabetes mellitus (T2DM).Methods: Twenty-four ZDF-Leprfa/fa rats were randomized to: (1) ZDF group (n = 8); (2) ZDF + PIO (pioglitazone) group (n = 8); and (3) ZDF + EA group… Continue reading #Electroacupuncture modulates myocardial insulin signaling and inflammatory markers in a rat model of type 2 #diabetes
Total and specific #potato intake and risk of type 2 #diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
Objectives To investigate the associations between total and individual potato intake and risk of type 2 diabetes (T2D), estimate the effect on T2D risk of replacing potatoes with whole grains and other major carbohydrate sources, and conduct a dose-response and substitution meta-analysis of prospective cohort studies.Design Prospective cohort study and dose-response meta-analysis of prospective cohort… Continue reading Total and specific #potato intake and risk of type 2 #diabetes: results from three US cohort studies and a substitution meta-analysis of prospective cohorts
Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 #diabetes and metabolic pathway #dysregulation in a multiethnic US population
Growing evidence suggests that exposure to per- and polyfluoroalkyl substances ( #PFAS ) are linked to an increased risk of type 2 diabetes (T2D); however, the effect of PFAS mixtures and underlying mechanisms are not well understood. We examined the associations between exposure to PFAS mixture with later T2D diagnosis and underlying metabolic dysregulations.MethodsWe conducted… Continue reading Exposure to per- and poly-fluoroalkyl substances in association to later occurrence of type 2 #diabetes and metabolic pathway #dysregulation in a multiethnic US population
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