Purpose: Data on the reliability of point-of-care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) #D-dimer (DD), interleukin 6 (IL-6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL-6 and PCT in comparison… Continue reading Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection
Tag: D
Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
Background: #D-dimer has gained considerable attention since its inclusion as a minor criterion in the 2018 International Consensus Meeting. However, evidence regarding its diagnostic accuracy for periprosthetic joint infection ( #PJI ) remains inconclusive. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of D-dimer in diagnosing PJI and comprehensively explore the sources… Continue reading Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration
Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression. Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between vitamin D deficiency and autoimmunity. We find that mice lacking Cyp27b1, which cannot… Continue reading Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin #D signaling
Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
IntroductionApproximately 30% to 50% residual β-cell function may remain at the time of type 1 diabetes (T1D) diagnosis, and this may persist for months or years.1,2 A prolonged partial remission (PR) phase of T1D leads to improved glycemic control and decreased long-term complications.1 We previously reported1 that ergocalciferol significantly decreased circulating tumor necrosis factor (TNF)-α and temporal trends… Continue reading Effect of #Ergocalciferol on β-Cell Function in New-Onset Type 1 #Diabetes A Secondary Analysis of a Randomized Clinical Trial
2 Medical News 