BackgroundHuman hookworm has been proposed as a treatment for ulcerative colitis (UC). This pilot study assessed the feasibility of a full-scale randomized control trial examining hookworm to maintain clinical remission in patients with UC.MethodsTwenty patients with UC in disease remission (Simple Clinical Colitis Activity Index [SCCAI] ≤4 and fecal calprotectin (fCal) <100 ug/g) and only… Continue reading Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial
Category: Infectivology
IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein
Less than a year after the global emergence of the coronavirus SARS-CoV-2, a novel vaccine platform based on mRNA technology was introduced to the market. Globally, around 13.38 billion COVID-19 vaccine doses of diverse platforms have been administered. To date, 72.3% of the total population has been injected at least once with a COVID-19 vaccine.… Continue reading IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein
Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021
Vaccination against COVID-19 provides clear public health benefits, but vaccination also carries potential risks. The risks and outcomes of myocarditis after COVID-19 vaccination are unclear.Objective To describe reports of myocarditis and the reporting rates after mRNA-based COVID-19 vaccination in the US.Design, Setting, and Participants Descriptive study of reports of myocarditis to the Vaccine Adverse Event Reporting System… Continue reading Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021
Cranberries for preventing urinary tract infections
Cranberries contain proanthocyanidins (PACs), which inhibit the adherence of p‐fimbriated Escherichia coli to the urothelial cells lining the bladder. Cranberry products have been used widely for several decades to prevent urinary tract infections (UTIs). This is the fifth update of a review first published in 1998 and updated in 2003, 2004, 2008, and 2012.ObjectivesTo assess… Continue reading Cranberries for preventing urinary tract infections
Early Treatment with Hydroxychloroquine and Azithromycin: A ‘Real-Life’ Monocentric Retrospective Cohort Study of 30,423 COVID-19 Patients
AbstractObjective To estimate the comparative effectiveness of combination therapy with hydroxychloroquine (HCQ) and azithromycin for coronavirus disease 2019 (COVID-19)- related death based on a large monocentric cohort independent of investigators’ putative biases in a real-world setting.Design Retrospective monocentric cohort study, with comprehensive data collection authenticated by an external bailiff and death reports from a national… Continue reading Early Treatment with Hydroxychloroquine and Azithromycin: A ‘Real-Life’ Monocentric Retrospective Cohort Study of 30,423 COVID-19 Patients
Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Highlights•Meat may be an important vehicle for human exposure to extraintestinal pathogenic E. coli strains from food animals.•We present a novel approach for predicting the origins of clinical E. coli isolates.•Approximately 8% of the clinical E. coli isolates in our population appeared to be foodborne zoonotic strains.•Foodborne zoonotic E. coli strains were associated with asymptomatic… Continue reading Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Multiple lines of evidence support the value of moderate fever to host survival, but the mechanisms involved remain unclear. This is difficult to establish in warm-blooded animal models, given the strict programmes controlling core body temperature and the physiological stress that results from their disruption. Thus, we took advantage of a cold-blooded teleost fish that… Continue reading Fever integrates antimicrobial defences, inflammation control, and tissue repair in a cold-blooded vertebrate
Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Highlights •Circulating monocytes migrate to the bone marrow upon fasting•Monocytes augment CXCR4 via a fasting-induced hormonal stress response•Re-feeding after prolonged fasting results in a surge of monocytes into circulation•Prolonged fasting and re-feeding alter the immune response to bacterial infection SummaryDiet profoundly influences physiology. Whereas over-nutrition elevates risk for disease via its influence on immunity and… Continue reading Monocytes re-enter the bone marrow during fasting and alter the host response to infection
Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report
A 71-year-old man was transferred urgently to our hospital after collapsing near his home post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, Comirnaty®). Immediately after arrival at our hospital, cardiac arrest due to complete atrioventricular block with no ventricular escaped beats was observed on electrocardiogram. Echocardiography showed preserved left ventricular ejection… Continue reading Fulminant myocarditis with complete atrioventricular block after mRNA COVID-19 vaccination: A case report
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