Following on from a thorough review of the evidence carried out by the MHRA, and recommendation by the Commission on Human Medicines (CHM), the government’s independent expert scientific advisory body, the MHRA has approved Ronapreve as the first monoclonal antibody combination product indicated for use in the prevention and treatment of acute COVID-19 infection for… Continue reading First #monoclonal antibody treatment for #COVID-19 approved for use in the UK
Category: Infectivology
Early detection of #COVID-19 in the UK using self-reported #symptoms: a large-scale, prospective, epidemiological surveillance study
.. The early detection of COVID-19 is helpful for resource allocation during the pandemic. Here, we have proposed a Bayesian approach to identify individuals with probable COVID-19 on the basis of self-reported symptoms during 1, 2, and 3 days after symptom onset and demographic information. Using a unique, prospective dataset, we evaluated the proposed method… Continue reading Early detection of #COVID-19 in the UK using self-reported #symptoms: a large-scale, prospective, epidemiological surveillance study
Infection-enhancing anti-#SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and #Delta variants. A potential risk for mass vaccination ?
Infection-enhancing antibodies have been detected in symptomatic Covid-19•Antibody dependent enhancement (ADE) is a potential concern for vaccines•Enhancing antibodies recognize both the Wuhan strain and Delta variants•ADE of Delta variants is a potential risk for current vaccines•Vaccine formulations lacking ADE epitope are suggested AbstractAntibody dependent enhancement (ADE) of infection is a safety concern for vaccine strategies.… Continue reading Infection-enhancing anti-#SARS-CoV-2 antibodies recognize both the original Wuhan/D614G strain and #Delta variants. A potential risk for mass vaccination ?
#Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study
A new syndrome of vaccine-induced immune thrombotic thrombocytopenia (VITT) has emerged as a rare side-effect of vaccination against COVID-19. Cerebral venous thrombosis is the most common manifestation of this syndrome but, to our knowledge, has not previously been described in detail. We aimed to document the features of post-vaccination cerebral venous thrombosis with and without… Continue reading #Cerebral venous #thrombosis after vaccination against #COVID-19 in the UK: a multicentre cohort study
Identification of #antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results
Some antibiotic pairs display a property known as collateral sensitivity in which the evolution of resistance to one antibiotic increases sensitivity to the other. Alternating between collaterally sensitive antibiotics has been proposed as a sustainable solution to the problem of antibiotic resistance. We aimed to identify antibiotic pairs that could be considered for treatment strategies… Continue reading Identification of #antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results
Mortality among persons who inject #drugs: A prospective cohort followed over three decades in Baltimore, Maryland, USA
Over the past decades, people who inject drugs (PWID) have been impacted by the development of combination antiretroviral therapy (cART) to combat HIV/AIDS, the prescription opioid crisis, and increased use of lethal synthetic opioids. We measured how these dynamics have impacted mortality among PWID in an urban U.S. city. DesignProspective cohort study using data from… Continue reading Mortality among persons who inject #drugs: A prospective cohort followed over three decades in Baltimore, Maryland, USA
Covid-19: #Delta infections threaten herd immunity #vaccine strategy
Epidemiologists are adjusting their expectations for the future course of the pandemic after data from a recent outbreak in Massachusetts in the US suggest that while vaccination remains highly protective against the worst consequences of infection, it may not be sufficient on its own to stop the spread of the delta variant. Testing conducted among… Continue reading Covid-19: #Delta infections threaten herd immunity #vaccine strategy
‘Mathematically Impossible’ for #Vaccines to Eliminate #COVID
The latest data suggest the wave of COVID among unvaccinated has peaked and natural herd immunity has set in, while vaccinated individuals are actually becoming more prone to infection The Defender is experiencing censorship on many social channels. Be sure to stay in touch with the news that matters by subscribing to our top news… Continue reading ‘Mathematically Impossible’ for #Vaccines to Eliminate #COVID
Functional human #IgA targets a conserved site on #malaria sporozoites
A role for IgA in malariaImmunoglobulin (Ig)A is known to play a protective role against pathogens at mucosal surfaces. However, the protective effects of IgA in the serum are less well understood, particularly in the context of pathogens such as Plasmodium falciparum. To address this question, Tan et al. isolated and characterized serum IgA from… Continue reading Functional human #IgA targets a conserved site on #malaria sporozoites
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