The mRNA coronavirus disease 2019 (COVID-19) vaccines have shown high effectiveness in the prevention of symptomatic COVID-19, hospitalization, severe disease and death. Nevertheless, a minority of vaccinated individuals might become infected and experience significant morbidity. Characteristics of vaccine breakthrough infections have not been studied. We sought to portray the population of Israeli patients, who were… Continue reading BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully #vaccinated hospitalized #COVID-19 patients in Israel
Category: Infectivology
Considerations in boosting #COVID-19 #vaccine immune responses
A new wave of COVID-19 cases caused by the highly transmissible delta variant is exacerbating the worldwide public health crisis, and has led to consideration of the potential need for, and optimal timing of, booster doses for vaccinated populations.1 Although the idea of further reducing the number of COVID-19 cases by enhancing immunity in vaccinated… Continue reading Considerations in boosting #COVID-19 #vaccine immune responses
#Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
COVID-19 induces a robust, extended inflammatory “cytokine storm” that contributes to an increased morbidity and mortality, particularly in patients with type 2 diabetes (T2D). Macrophages are a key innate immune cell population responsible for the cytokine storm that has been shown, in T2D, to promote excess inflammation in response to infection. Using peripheral monocytes and… Continue reading #Coronavirus induces #diabetic macrophage-mediated inflammation via SETDB2
#Probenecid inhibits #SARS-CoV-2 replication in vivo and in vitro
Effective vaccines are slowing the COVID-19 pandemic, but SARS-CoV-2 will likely remain an issue in the future making it important to have therapeutics to treat patients. There are few options for treating patients with COVID-19. We show probenecid potently blocks SARS-CoV-2 replication in mammalian cells and virus replication in a hamster model. Furthermore, we demonstrate… Continue reading #Probenecid inhibits #SARS-CoV-2 replication in vivo and in vitro
#Metoprolol in Critically Ill Patients With COVID-19
Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting. ObjectivesThe purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respiratory function in… Continue reading #Metoprolol in Critically Ill Patients With COVID-19
#Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines
Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasiticivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty: We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection.… Continue reading #Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines
#COVID-19 Transmission Dynamics Among Close #Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China
Much remains unknown about the transmission dynamics of COVID-19. How the severity of the index case and timing of exposure is associated with disease in close contacts of index patients with COVID-19 and clinical presentation in those developing disease is not well elucidated. Objectives To investigate the association between the timing of exposure and development… Continue reading #COVID-19 Transmission Dynamics Among Close #Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China
Limited protection against #SARS-CoV-2 infection and virus transmission after mRNA #vaccination
Stang and coworkers have recently reported in the Journal that “RT-PCR test results as gold standard for assessing and controlling infectiousness fail”[1]. The authors analyzed two scenarios and used Ct25 and Ct30 as thresholds for infectiousness and conclude that more than the half of their patient cohort was unlikely to have been infectious, i.e. the… Continue reading Limited protection against #SARS-CoV-2 infection and virus transmission after mRNA #vaccination
Association of poor #housing conditions with #COVID-19 incidence and mortality across US counties
Poor housing conditions have been linked with worse health outcomes and infectious disease spread. Since the relationship of poor housing conditions with incidence and mortality of COVID-19 is unknown, we investigated the association between poor housing condition and COVID-19 incidence and mortality in US counties. MethodsWe conducted cross-sectional analysis of county-level data from the US… Continue reading Association of poor #housing conditions with #COVID-19 incidence and mortality across US counties
2 Medical News 