Since nucleoside-modified mRNA vaccines strongly activate T follicular helper cells, it is important to explore the possible impact of approved SARS-CoV-2 mRNA vaccines on neoplasms affecting this cell type. Herein, we report and discuss unexpected rapid progression of lymphomatous lesions after administration of a BNT162b2 mRNA vaccine booster in a man recently diagnosed with AITL.… Continue reading Rapid Progression of Angioimmunoblastic T Cell Lymphoma Following BNT162b2 mRNA Vaccine Booster Shot: A Case Report
Tag: Vaccines
Clinical Presentation and Outcomes of Myocarditis Post mRNA Vaccination: A Meta-Analysis and Systematic Review
AbstractBackground: Myocarditis is being increasingly reported as a potential complication of both Pfizer-BioNTech and Moderna vaccines for COVID-19. One thousand five hundred and twenty-two cases were reported as of September 02, 2021, as per CDC’s (Centers for Disease Control) vaccine adverse event reporting system. Most of the published data is available in the form of… Continue reading Clinical Presentation and Outcomes of Myocarditis Post mRNA Vaccination: A Meta-Analysis and Systematic Review
Transparency of COVID-19 vaccine trials: decisions without data
Summary boxData transparency has become a well-established norm in biomedical research, and is especially important for broadly used public health interventions like COVID-19 vaccines. Tax payers helped fund COVID-19 vaccine trials and should have the right to access the results. There is inadequate availability of COVID-19 vaccine trial documents and data; individual participant data will… Continue reading Transparency of COVID-19 vaccine trials: decisions without data
Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA
Flu defense via lung-resident IgA+ memory B cellsSecretory IgA antibody is known to be a key effector molecule in establishing effective antiviral immunity in the lungs, but the specific cell types producing this mucosal IgA and their physical locations are unclear. Oh et al. analyzed pulmonary IgA-secreting cells in mice after prior influenza infection or… Continue reading Intranasal priming induces local lung-resident B cell populations that secrete protective mucosal antiviral IgA
Increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
The extent to which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOC) break through infection- or vaccine-induced immunity is not well understood. Here, we analyze 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. We find evidence for… Continue reading Increased risk of infection with SARS-CoV-2 Beta, Gamma, and Delta variant compared to Alpha variant in vaccinated individuals
The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America
The importance of understanding SARS-CoV-2 evolution cannot be overemphasized. Recent studies confirm that natural selection is the dominating mechanism of SARS-CoV-2 evolution, which favors mutations that strengthen viral infectivity. We demonstrate that vaccine-breakthrough or antibody-resistant mutations provide a new mechanism of viral evolution. Specifically, vaccine-resistant mutation Y449S in the spike (S) protein receptor-bonding domain (RBD),… Continue reading The evolution of the mechanisms of SARS-CoV-2 evolution revealing vaccine-resistant mutations in Europe and America
Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical interventions. With the emergence of new strains of SARS-CoV-2 with altered… Continue reading Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein
COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study
There has been increasing public concern that COVID-19 vaccines cause menstrual cycle disturbances, yet there is currently limited data to evaluate the impact of vaccination on menstrual health. Our objectives were (1) to evaluate the prevalence of menstrual changes following vaccination against COVID-19, (2) to test potential risk factors for any such changes, and (3)… Continue reading COVID-19 vaccination and menstrual cycle changes: A United Kingdom (UK) retrospective case-control study
Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types
An increasing number of myocarditis/pericarditis incidences has been reported after coronavirus disease-19 (COVID-19) vaccination in adolescents and young adults. This study was designed to investigate the incidence rate of—and risk for—myocarditis and pericarditis following COVID-19 vaccination in the United States according to age and vaccine type. This study used the Vaccine Adverse Events Reporting System… Continue reading Myocarditis and Pericarditis following COVID-19 Vaccination: Inequalities in Age and Vaccine Types
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