Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and difficult to predict. This is a major challenge for effective clinical management.Objective We aimed to provide accurate AN risk stratification in UC patients with LGD. We hypothesised that… Continue reading Low-coverage whole genome sequencing of low-grade #dysplasia strongly predicts advanced neoplasia risk in ulcerative #colitis
Tag: ulcerative-colitis
Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial
BackgroundHuman hookworm has been proposed as a treatment for ulcerative colitis (UC). This pilot study assessed the feasibility of a full-scale randomized control trial examining hookworm to maintain clinical remission in patients with UC.MethodsTwenty patients with UC in disease remission (Simple Clinical Colitis Activity Index [SCCAI] ≤4 and fecal calprotectin (fCal) <100 ug/g) and only… Continue reading Controlled Hookworm Infection for Medication-free Maintenance in Patients with Ulcerative Colitis: A Pilot, Double-blind, Randomized Control Trial
Lifestyle factors for the prevention of inflammatory bowel disease
Objective To estimate the proportion of cases of Crohn’s disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.Design In a prospective cohort study of US adults from the Nurses’ Health Study (NHS; n=72 290), NHSII (n=93 909) and Health Professionals Follow-up Study (HPFS; n=41 871), we created modifiable risk scores (MRS; 0–6) for CD and… Continue reading Lifestyle factors for the prevention of inflammatory bowel disease
Computational drug repositioning of #atorvastatin for ulcerative #colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-world heterogeneity of UC would identify a robust transcriptomic signature to improve identification of FDA-approved drugs that can be repurposed to treat patients with UC. Materials… Continue reading Computational drug repositioning of #atorvastatin for ulcerative #colitis
Heterogeneity and clonal relationships of adaptive immune cells in #ulcerative colitis revealed by single-cell analyses
Inflammatory bowel disease (IBD) encompasses a spectrum of gastrointestinal disorders driven by dysregulated immune responses against gut microbiota. We integrated single-cell RNA and antigen receptor sequencing to elucidate key components, cellular states, and clonal relationships of the peripheral and gastrointestinal mucosal immune systems in health and ulcerative colitis (UC). UC was associated with an increase… Continue reading Heterogeneity and clonal relationships of adaptive immune cells in #ulcerative colitis revealed by single-cell analyses
#Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
Secondary bile acids (SBAs) are derived from primary bile acids (PBAs) in a process reliant on biosynthetic capabilities possessed by few microbes. To evaluate the role of BAs in intestinal inflammation, we performed metabolomic, microbiome, metagenomic, and transcriptomic profiling of stool from ileal pouches (surgically created resevoirs) in colectomy-treated patients with ulcerative colitis (UC) versus… Continue reading #Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation
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