Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis

Low-dose glucocorticoids are frequently used for the management of rheumatoid arthritis (RA) and other chronic conditions, but the safety of long-term use remains uncertain.. ..Associations between glucocorticoid dose (none, ≤5 mg/d, >5 to 10 mg/d, and >10 mg/d) and hospitalized infection were evaluated using inverse probability–weighted analyses, with 1-year cumulative incidence predicted from weighted models.… Continue reading Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis

#Depression and subsequent risk for incident rheumatoid #arthritis among women

We investigated the association of depression with subsequent risk of rheumatoid arthritis (RA) by serologic phenotype.. ..Among 195,358 women, we identified 858 incident RA cases (65% seropositive) over 3,087,556 person‐years (median 17.9 years/participant). Compared to women without depression, those with depression had multivariable HRs (95%CIs) of: 1.28(1.10‐1.48) for all RA; 1.12(0.93‐1.35) for seropositive RA; and… Continue reading #Depression and subsequent risk for incident rheumatoid #arthritis among women

Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis

Patients with rheumatoid arthritis (RA) are at high risk for cardiovascular (CV) mortality, attributed to chronic inflammation coupled with elevated circulatory homocysteine levels. Increasing the serum folate level reduces homocysteine, but the association of serum folate concentration with CV mortality in patients with RA has not been previously examined.. A total of 683 patients with… Continue reading Association of Serum #Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid #Arthritis