This study aimed to investigate the association between dietary vitamin K intake and all-cause mortality in individuals with non-alcoholic fatty liver disease (NAFLD). We analyzed data from 7857 NAFLD participants in the National Health and Nutrition Examination Survey (NHANES 2005–2018) linked to mortality outcomes from the National Death Index (NDI). Dietary vitamin K intake was… Continue reading Dietary vitamin #K intake associates with reduced all-cause #mortality in non-alcoholic #fatty #liver disease patients
Tag: NAFLD
Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
Acetyl-CoA synthetase short-chain family member 1 (ACSS1) uses acetate to generate mitochondrial acetyl-CoA and is regulated by deacetylation by sirtuin 3. We generated an ACSS1-acetylation (Ac) mimic mouse, where lysine-635 was mutated to glutamine (K635Q). Male Acss1K635Q/K635Q mice were smaller with higher metabolic rate and blood acetate and decreased liver/serum ATP and lactate levels. After a 48-hour… Continue reading Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered metabolism, cell senescence, and nonalcoholic fatty #liver disease
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Importance Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.Design, Setting, and Participants This cohort study used data from the National Health and Nutrition… Continue reading Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases, whose severe form is associated with oxidative stress. Vitamin E as an antioxidant has a protective potential in NAFLD. Whether dietary intake of vitamin E, supplementary vitamin E use, and total vitamin E have a preventive effect on NAFLD requires investigation.… Continue reading Vitamin #E intake is inversely associated with #NAFLD measured by liver ultrasound transient elastography
Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Evidence regarding the effect of dietary niacin intake on the risk of mortality among patients with nonalcoholic fatty liver disease (NAFLD) is scarce.Objective To examine the association of dietary niacin intake with all-cause mortality and cardiovascular disease (CVD) mortality among individuals with NAFLD.Design, Setting, and Participants This cohort study used data from the National Health and Nutrition… Continue reading Dietary #Niacin Intake and Mortality Among Individuals With Nonalcoholic #Fatty #Liver Disease
Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
Nonalcoholic fatty liver disease (NAFLD)-related fibrosis is heritable, but it is unclear how family history may be used to identify first-degree relatives with advanced fibrosis. We aimed to develop and validate a simple risk score to identify first-degree relatives of probands who have undergone assessment of liver fibrosis who are at higher risk of NAFLD… Continue reading Development and Validation of the Nonalcoholic #Fatty Liver Disease Familial Risk Score to Detect Advanced #Fibrosis: A Prospective, Multicenter Study
Association between diet soft #drink consumption and #metabolic dysfunction-associated #steatotic liver disease: findings from the NHANES
Lifestyle change plays a crucial role in the prevention and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). In recent years, diet soft drinks that emphasize “zero sugar and zero calories” have become all the rage, but whether diet soft drink consumption is associated with MASLD is not clear.MethodsThis study included data from the National… Continue reading Association between diet soft #drink consumption and #metabolic dysfunction-associated #steatotic liver disease: findings from the NHANES
Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
Clinical and preclinical studies established that supplementing diets with ω3 polyunsaturated fatty acids (PUFA) can reduce hepatic dysfunction in nonalcoholic steatohepatitis (NASH) but molecular underpinnings of this action were elusive. Herein, we used multi-omic network analysis that unveiled critical molecular pathways involved in ω3 PUFA effects in a preclinical mouse model of western diet induced… Continue reading Multi-omic network analysis identified #betacellulin as a novel target of #omega-3 fatty acid attenuation of western diet-induced nonalcoholic #steatohepatitis
The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
Non-Alcoholic Fatty Liver Disease (NAFLD) has emerged as a significant public health concern, affecting millions of individuals worldwide. Characterized by the accumulation of fat in the liver without excessive alcohol consumption, NAFLD can progress to more severe conditions, such as non-alcoholic steatohepatitis (NASH) and cirrhosis. While lifestyle modifications remain a cornerstone in managing NAFLD, recent… Continue reading The Potential Role of Vitamin #E in Managing Non-Alcoholic Fatty #Liver Disease: Insights from Japan’s Aichi Medical University Study
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