Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.

During the menopause women may experience increased oxidative stress and decreased antioxidant capacity and, together with the decline of neurosteroids, this represents a risk factor for Alzheimer's disease. The aim of the present study was to test a functional food (FPP-ORI, Osato Research Institute, Gifu, Japan) on redox and mitochondrial efficiency in post-menopausal women. The… Continue reading Mitochondrial and redox dysfunction in post-#menopause as risk factor of neurodegenerative disease: a pilot study testing the role of a validated Japanese functional food.

Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression

Cardiovascular disease (CVD) is the leading cause of death in western countries. One risk factor unique to women is the menopausal status. The aim of this study was to analyse the influence of the onset of menopause (MP) on the extent and progression of atherosclerotic plaque volume (PV). ..110 consecutive postmenopausal women (mean age 65.5)… Continue reading Early onset of #menopause is associated with increased peripheral #atherosclerotic plaque volume and progression

Effect of hormone replacement therapy on #atherogenic lipid profile in postmenopausal women

..Recent studies suggest that hormone replacement therapy (#HRT) is cardioprotective when initiated early after menopause, but the mechanisms involved are still unclear. One-hundred and forty postmenopausal women <70 years were included in EVTET and randomized either to active treatment (one tablet of 2 mg estradiol and 1 mg norethisterone acetate daily) (n = 71) or placebo (n = 69). Our study show… Continue reading Effect of hormone replacement therapy on #atherogenic lipid profile in postmenopausal women