Background: Cognitive decline is a common aspect of aging, and identifying modifiable lifestyle factors-such as physical activity and sleep-are crucial for promoting healthy brain aging. While both are individually linked to cognition, few studies have simultaneously assessed their independent and combined effects using objective wearable-based data, particularly in older Asian populations.Objective: This study aimed to… Continue reading Associations of #Wearable- Measured #Sleep and #Physical Activity With #Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI
Tag: memory
A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
As viable pharmacotherapies and blood biomarkers emerge for dementia treatment and screening, there remains a great need for accurate, sensitive biomarkers of cognitive function. We have previously demonstrated that Fastball, a new Electroencephalography (EEG) method for the passive and objective measurement of recognition memory that requires no behavioural memory response or task comprehension, is sensitive… Continue reading A passive and objective measure of recognition memory in mild #cognitive #impairment using Fastball #memory assessment
Fine-Tuning the Details: Post-encoding #Music Differentially Impacts General and Detailed #Memory
Music can effectively induce emotional arousal, which is associated with the release of stress hormones that are important for the emotional modulation of memory. Thus, music may serve as a powerful modulator of memory and mood, making it a promising therapeutic tool for memory and mood disorders such as Alzheimer's disease or depression. However, music's… Continue reading Fine-Tuning the Details: Post-encoding #Music Differentially Impacts General and Detailed #Memory
Decoding #memory function through naturalistic gaze patterns
#Eye movements are closely linked to encoding and retrieval processes, with changes in viewing behavior reflecting age- and pathology-related memory decline. In the current study, we leveraged this relationship to explore possible gaze-based indicators of memory function. Across two task-free viewing experiments, we investigated changes in naturalistic viewing behavior across five participant groups spanning a… Continue reading Decoding #memory function through naturalistic gaze patterns
#Sleep selectively and durably enhances #memory for the sequence of real-world experiences
Sleep is thought to play a critical role in the retention of memory for past experiences (episodic memory), reducing the rate of forgetting compared with wakefulness. Yet it remains unclear whether and how sleep actively transforms the way we remember multidimensional real-world experiences, and how such memory transformation unfolds over the days, months and years… Continue reading #Sleep selectively and durably enhances #memory for the sequence of real-world experiences
The massed-spaced #learning effect in non-neural human #cells
The massed-spaced effect is a hallmark feature of memory formation. We now demonstrate this effect in two separate non-neural, immortalized cell lines stably expressing a short-lived luciferase reporter controlled by a CREB-dependent promoter. We emulate training using repeated pulses of forskolin and/or phorbol ester, and, as a proxy for memory, measure luciferase expression at various… Continue reading The massed-spaced #learning effect in non-neural human #cells
Membrane potential states gate #synaptic consolidation in human neocortical tissue
Synaptic mechanisms that contribute to human memory consolidation remain largely unexplored. Consolidation critically relies on sleep. During slow wave sleep, neurons exhibit characteristic membrane potential oscillations known as UP and DOWN states. Coupling of memory reactivation to these slow oscillations promotes consolidation, though the underlying mechanisms remain elusive. Here, we performed axonal and multineuron patch-clamp… Continue reading Membrane potential states gate #synaptic consolidation in human neocortical tissue
A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Editor’s summaryDuring sleep, there is an increase in the coordinated firing of neuronal ensembles that were previously active during behavior. These hippocampal sharp-wave ripples are necessary for sleep-dependent memory consolidation. However, how the hippocampus regulates such increases in ensemble reactivation and synchrony while keeping the overall homeostatic balance of the network is not known. Karaba et… Continue reading A #hippocampal circuit mechanism to balance #memory reactivation during #sleep
Cortical reactivations predict future sensory responses
Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern1,2. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences3,4,5,6. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium… Continue reading Cortical reactivations predict future sensory responses
2 Medical News 