Are melanomas diagnosed through routine skin checks (a proxy for skin cancer screening) associated with reduced melanoma-specific and all-cause mortality? Findings This population-based cohort study included 2452 patients, each with 1 diagnosed melanoma, 35% of which were detected during a routine skin check. In multivariable analyses, routine skin-check detection was associated with a subhazard ratio… Continue reading Association Between #Melanoma Detected During Routine Skin Checks and Mortality
Tag: Melanoma
Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients
Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overcome by changing the gut microbiota, this clinical trial evaluated the safety and efficacy of… Continue reading Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients
Association of Indoor #Tanning Exposure With Age at #Melanoma Diagnosis and BRAF V600E Mutations
..The 114 patients who reported indoor tanning exposure were younger at diagnosis than the 222 patients who did not (51.5 vs 64.0 years, two-sided P < .001). BRAF V600E genotype was more prevalent in ever-users than in nonusers (42.9% vs 28.3%, two-sided P = .04) and higher in ever-users who initiated indoor tanning prior to age… Continue reading Association of Indoor #Tanning Exposure With Age at #Melanoma Diagnosis and BRAF V600E Mutations
Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role… Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
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