INTRODUCTIONIn mammals, the early-life period after birth is a time of profound immune development during which the generation of appropriate responses to newly encountered commensal and environmental antigens is crucial for maintaining health. Breast milk is positioned to regulate nascent mucosal immune responses through the delivery of live microbes, commensal-selecting oligosaccharides, maternal cells, and immunomodulatory… Continue reading Breast #milk IgG engages the mouse #neonatal #immune system to instruct responses to #gut #antigens
Tag: immunity
Immunocompromised children and young people are at no increased risk of severe COVID-19
Highlights•UK immunocompromised paediatric patients were at no increased risk of severe COVID-19. •Only 4/38 PCR detected infections were admitted to hospital. None had acute severe COVID-19 or died. •Increasing age and immunodeficiency increased reporting of SARS-CoV-2 infection. Worsening of fever, cough and sore throat were associated with reporting SARS-CoV-2 infection. •Serology results suggest there was… Continue reading Immunocompromised children and young people are at no increased risk of severe COVID-19
Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
Determination of SARS-CoV-2 antibody responses in the context of pre-existing immunity to circulating human coronavirus (HCoV) is critical for understanding protective immunity. Here we perform a multifactorial analysis of SARS-CoV-2 and HCoV antibody responses in pre-pandemic (N = 825) and SARS-CoV-2-infected donors (N = 389) using a custom-designed multiplex ABCORA assay. ABCORA seroprofiling, when combined with computational modeling, enables… Continue reading Multifactorial seroprofiling dissects the contribution of pre-existing human coronaviruses responses to SARS-CoV-2 immunity
2 Medical News 