Antimicrobial resistance (AMR) poses a global threat to public health. While antibiotic overuse is a primary driver, emerging evidence suggests that non-antibiotic medications (NAMs) may also contribute. This concern is particularly relevant in residential aged care facilities (RACFs), where both NAMs and antibiotics are frequently used. We investigated whether nine commonly used NAMs in RACFs,… Continue reading The effect of commonly used non- #antibiotic medications on #antimicrobial resistance development in #Escherichia coli
Tag: E.Coli
The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
Lipopolysaccharide (LPS) is the primary pathogenic factor in Gram-negative sepsis. While the presence of LPS in the bloodstream during infection is associated with disseminated intravascular coagulation, the mechanistic link between LPS and blood coagulation activation remains ill-defined. The contact pathway of coagulation—a series of biochemical reactions that initiates blood clotting when plasma factors XII (FXII)… Continue reading The physicochemical properties of #lipopolysaccharide chemotypes regulate activation of the contact pathway of blood coagulation
Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Highlights•Meat may be an important vehicle for human exposure to extraintestinal pathogenic E. coli strains from food animals.•We present a novel approach for predicting the origins of clinical E. coli isolates.•Approximately 8% of the clinical E. coli isolates in our population appeared to be foodborne zoonotic strains.•Foodborne zoonotic E. coli strains were associated with asymptomatic… Continue reading Using source-associated mobile genetic elements to identify zoonotic extraintestinal E. coli infections
Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
Fecal microbiota transplantation (#FMT) is an emerging therapy for recurrent or refractory Clostridioides difficile infection and is being actively investigated for other conditions. We describe two patients in whom extended-spectrum beta-lactamase (ESBL)–producing Escherichia coli bacteremia occurred after they had undergone FMT in two independent clinical trials; both cases were linked to the same stool donor… Continue reading Drug-Resistant E. #coli Bacteremia Transmitted by Fecal Microbiota Transplant
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