Intact global #cognitive and #olfactory ability predicts lack of transition to #dementia

Odor identification deficits characterize Alzheimer's disease and other dementias ..Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT) ..In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among participants with intact olfactory (B-SIT ≥ 11/12… Continue reading Intact global #cognitive and #olfactory ability predicts lack of transition to #dementia

Serum elaidic acid concentration and risk of #dementia. The Hisayama study

The associations between #trans fatty acids and dementia have been unclear. We investigated the prospective association between serum elaidic acid (trans 18:1 n-9) levels, as an objective biomarker for industrial trans fat, and incident dementia and its subtypes. Higher serum elaidic acid levels were significantly associated with greater risk of developing all-cause dementia (p for… Continue reading Serum elaidic acid concentration and risk of #dementia. The Hisayama study

Association Between High School #Personality Phenotype and #Dementia 54 Years Later in Results From a National US Sample

To examine whether personality during adolescence—a time when preclinical dementia pathology is unlikely to be present—confers risk of dementia in later life and to test whether associations could be accounted for by health factors in adolescence or differed across socioeconomic status (SES). Lower risk of dementia was associated with higher levels of vigor (hazard ratio… Continue reading Association Between High School #Personality Phenotype and #Dementia 54 Years Later in Results From a National US Sample

Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment

Findings were consistent when stratified by sex, age, and APOE E4 genotype. Compared with drinking less than 1.0 drink per week, complete abstention (in participants without MCI) and the consumption of more than 14.0 drinks per week (in participants with MCI) were associated with lower Modified Mini-Mental State Examination scores (mean difference at follow-up compared… Continue reading Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment