coronavirus 2 (SARS-CoV-2) infection can spread rapidly within skilled nursing facilities. After identification of a case of Covid-19 in a skilled nursing facility, we assessed transmission and evaluated the adequacy of symptom-based screening to identify infections in residents.. ..Twenty-three days after the first positive test result in a resident at this skilled nursing facility, 57… Continue reading Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility
Tag: coronavirus
Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States
In analyses of the effectiveness of response measures to the outbreak of coronavirus disease 2019 (COVID-19), most studies have used the number of confirmed cases or deaths. However, case count is a conservative estimate of the actual number of infected individuals in the absence of community-wide serologic testing. Death count is a lagging metric and… Continue reading Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States
Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract
Abstract The factors mediating fatal SARS-CoV-2 infections are poorly understood. Here, we show that cigarette smoke causes a dose-dependent upregulation of Angiotensin Converting Enzyme 2 (ACE2), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data, we demonstrate that ACE2 is expressed in a subset of secretory cells in the respiratory tract. Chronic… Continue reading Cigarette #smoke exposure and inflammatory signaling increase the expression of the #SARS-CoV-2 receptor ACE2 in the respiratory tract
#Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis
Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19.. ..96 032 patients (mean… Continue reading #Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis
#Remdesivir for the Treatment of #Covid-19 — Preliminary Report
..We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days.… Continue reading #Remdesivir for the Treatment of #Covid-19 — Preliminary Report
Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear.. ..Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled… Continue reading Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
There are few primary care studies of the COVID-19 pandemic. We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network.. ..We identified 3802 SARS-CoV-2 test results, of which 587… Continue reading Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
ACUTE #KIDNEY INJURY IN PATIENTS HOSPITALIZED WITH #COVID-19
The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and April 5, 2020, at… Continue reading ACUTE #KIDNEY INJURY IN PATIENTS HOSPITALIZED WITH #COVID-19
A human monoclonal antibody blocking SARS-CoV-2 infection
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on… Continue reading A human monoclonal antibody blocking SARS-CoV-2 infection
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