..Discussion: Coronavirus disease 2019 can persist and result in prolonged illness. Our study shows persistence of symptoms in a third of ambulatory patients 30 to 45 days after diagnosis even if we assume that those lost to follow-up were all asymptomatic. Fatigue, dyspnea, and loss of taste or smell were the main persistent symptoms. These… Continue reading #COVID-19 #Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings
Tag: coronavirus
#IgA dominates the early neutralizing antibody response to #SARS-CoV-2
Abstract Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and comprised of of IgG, IgA and IgE. Here we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting cells and the presence of SARS-CoV-2-specific neutralizing antibodies in the serum, saliva and… Continue reading #IgA dominates the early neutralizing antibody response to #SARS-CoV-2
UK probes whether #COVID-19 vaccine caused #allergic reactions
LONDON (AP) — Britain’s medical regulator warned Wednesday that people with a history of serious allergic reactions shouldn’t get the COVID-19 vaccine from Pfizer and BioNTech, and investigators looked into whether two reactions on the first day of the U.K.’s vaccination program were linked to the shot. The advice was issued on a “precautionary basis,”… Continue reading UK probes whether #COVID-19 vaccine caused #allergic reactions
Post-lockdown SARS- #CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
Stringent COVID-19 control measures were imposed in Wuhan between January 23 and April 8, 2020. Estimates of the prevalence of infection following the release of restrictions could inform post-lockdown pandemic management. Here, we describe a city-wide SARS-CoV-2 nucleic acid screening programme between May 14 and June 1, 2020 in Wuhan. All city residents aged six… Continue reading Post-lockdown SARS- #CoV-2 nucleic acid screening in nearly ten million residents of Wuhan, China
Older Adults and the Mental Health Effects of #COVID-19
As the coronavirus disease 2019 (COVID-19) began to spread in the US in early 2020, older adults experienced disproportionately greater adverse effects from the pandemic including more severe complications, higher mortality, concerns about disruptions to their daily routines and access to care, difficulty in adapting to technologies like telemedicine, and concerns that isolation would exacerbate… Continue reading Older Adults and the Mental Health Effects of #COVID-19
Domestic #Travel During #COVID-19
Before You Consider Traveling Travel can increase your chance of spreading and getting COVID-19. Postponing travel and staying home is the best way to protect yourself and others from COVID-19. If you are considering traveling, here are some important questions to ask yourself and your loved ones beforehand. These questions can help you decide what… Continue reading Domestic #Travel During #COVID-19
Options to Reduce #Quarantine for Contacts of Persons with SARS-#CoV-2 Infection Using Symptom Monitoring and Diagnostic Testing
Local public health authorities determine and establish the quarantine options for their jurisdictions. CDC currently recommends a quarantine period of 14 days. However, based on local circumstances and resources, the following options to shorten quarantine are acceptable alternatives. Quarantine can end after Day 10 without testing and if no symptoms have been reported during daily… Continue reading Options to Reduce #Quarantine for Contacts of Persons with SARS-#CoV-2 Infection Using Symptom Monitoring and Diagnostic Testing
#Aprotinin Inhibits #SARS-CoV-2 Replication
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) is the cause of the current coronavirus disease 19 (COVID-19) pandemic. Protease inhibitors are under consideration as virus entry inhibitors that prevent the cleavage of the coronavirus spike (S) protein by cellular proteases. Herein, we showed that the protease inhibitor aprotinin (but not the protease inhibitor SERPINA1/alpha-1 antitrypsin)… Continue reading #Aprotinin Inhibits #SARS-CoV-2 Replication
Distinct #inflammatory profiles distinguish #COVID-19 from #influenza with limited contributions from #cytokine storm
We pursued a study of immune responses in COVID-19 and influenza cohorts. Compared to influenza patients, COVID-19 patients exhibited largely equivalent lymphocyte counts, fewer monocytes, and lower surface HLA-class II expression on select monocyte populations. Furthermore, decreased HLA-DR on intermediate monocytes was a significant predictor of COVID-19 disease severity. In contrast to prevailing assumptions about… Continue reading Distinct #inflammatory profiles distinguish #COVID-19 from #influenza with limited contributions from #cytokine storm
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