Odor identification deficits characterize Alzheimer's disease and other dementias ..Smell Identification Test, which includes the 12-item Brief Smell Identification Test (B-SIT) ..In covariate-adjusted survival analyses, impairment on the Blessed Orientation Memory Concentration Test and B-SIT each predicted dementia (n = 109), primarily Alzheimer's disease (n = 101). Among participants with intact olfactory (B-SIT ≥ 11/12… Continue reading Intact global #cognitive and #olfactory ability predicts lack of transition to #dementia
Tag: Alzheimer
Dietary #salt promotes cognitive impairment through tau phosphorylation
Dietary habits and vascular risk factors promote both #Alzheimer’s disease and cognitive impairment caused by vascular factors. Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protein and a hallmark of Alzheimer’s pathology, is also linked to vascular cognitive impairment. In mice, a salt-rich diet leads to cognitive dysfunction associated with a nitric oxide deficit in cerebral… Continue reading Dietary #salt promotes cognitive impairment through tau phosphorylation
Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial
..exploring the effects of chair yoga (CY), compared to music intervention (MI) and chair-based exercise (CBE) in this population. Using a cluster randomized controlled trial (RCT), 3 community sites were randomly assigned 1:1:1 to CY, MI, or CBE. Participants attended twice-weekly 45-minute sessions for 12 weeks.. The CY group improved significantly in quality of life… Continue reading Nonpharmacological Interventions to Manage #Dementia Symptoms in Community-Dwelling Older Adults: A Cluster Randomized Controlled Trial
Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Results Anticoagulation with dabigatran prevented memory decline, cerebral hypoperfusion, and toxic fibrin deposition in the AD mouse brain. In addition, long-term dabigatran treatment significantly reduced the extent of amyloid plaques, oligomers, phagocytic microglia, and infiltrated T cells by 23.7%, 51.8%, 31.3%, and 32.2%, respectively. Dabigatran anticoagulation also prevented AD-related astrogliosis and pericyte alterations, and maintained… Continue reading Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Risk of #rhabdomyolysis with #donepezil compared with rivastigmine or galantamine: a population-based cohort study
Donepezil, rivastigmine and galantamine are popular cholinesterase inhibitors used to manage the symptoms of #Alzheimer disease and other dementias; regulatory agencies in several countries warn about a possible risk of rhabdomyolysis.. ..The average age in our 2 groups was 81.1 years, and 61.4% of our population was female. Donepezil was associated with a higher risk… Continue reading Risk of #rhabdomyolysis with #donepezil compared with rivastigmine or galantamine: a population-based cohort study
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