Background: Parkinson's disease is associated with a dysbiotic, proinflammatory gut microbiome, disruptions to intestinal barrier functions, and immunological imbalance. Microbiota-produced short-chain fatty acids, such as propionic and butyric acid promote gut barrier integrity and immune regulation, but their impact on Parkinson's disease pathology remains mostly unknown.Methods: In a randomized double-blind prospective study, 72 people with… Continue reading Supplementation with #short-chain fatty acids and a #prebiotic improves clinical outcome in #Parkinson’s disease: a randomized double-blind prospective study
Category: Neurology
Validity and reliability of the perseverative #thinking questionnaire in patients with #fibromyalgia
Background: Patients with fibromyalgia often experience repetitive negative thinking, which contributes to psychological distress. The Perseverative Thinking Questionnaire (PTQ) is a tool designed to assess this cognitive pattern. However, its psychometric properties have not been tested in fibromyalgia.Objective: This study aimed to assess the validity and reliability of the PTQ in patients with fibromyalgia.Methods: A… Continue reading Validity and reliability of the perseverative #thinking questionnaire in patients with #fibromyalgia
#Amino acid metabolites as potential circulating biomarkers for #sarcopenia
Sarcopenia, characterized by the loss of muscle mass and strength, is a multifactorial disorder, including metabolic disturbance. Plasma amino acids (AAs) regulate muscle protein synthesis and breakdown. This study evaluated plasma AA metabolites as potential biomarkers for sarcopenia using metabolomic analysis. We assessed 31 AA metabo lites in an age-matched discovery cohort (72 men, 36… Continue reading #Amino acid metabolites as potential circulating biomarkers for #sarcopenia
Associations of #Wearable- Measured #Sleep and #Physical Activity With #Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI
Background: Cognitive decline is a common aspect of aging, and identifying modifiable lifestyle factors-such as physical activity and sleep-are crucial for promoting healthy brain aging. While both are individually linked to cognition, few studies have simultaneously assessed their independent and combined effects using objective wearable-based data, particularly in older Asian populations.Objective: This study aimed to… Continue reading Associations of #Wearable- Measured #Sleep and #Physical Activity With #Memory Performance in Older Adults: Cross-Sectional Study With Actigraphy and MRI
Association Between Wake-Time #Movement Behaviors and #Weight Loss Maintenance
We examined whether wake-time movement composition was associated with weight loss maintenance among individuals who experienced clinically meaningful weight loss (> 5% of initial weight) using compositional data analysis.MethodsThis was a secondary analysis from a behavioral weight loss maintenance intervention on weight regain over 12 months following clinically meaningful 3-month weight loss. Body weight was assessed… Continue reading Association Between Wake-Time #Movement Behaviors and #Weight Loss Maintenance
Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
Physical inactivity is a recognized modifiable risk factor for Alzheimer’s disease (AD), yet its relationship with progression of AD pathology in humans remains unclear, limiting the effective translation into prevention trials. Using pedometer-measured step counts in cognitively unimpaired older adults, we demonstrated an association between higher physical activity and slower cognitive and functional decline in… Continue reading Physical #activity as a modifiable risk factor in preclinical #Alzheimer’s disease
High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Background and AimsThis study hypothesizes that subclinical myocardial injury during midlife, indexed by increases in cardiac troponin I, is associated with accelerated cognitive decline, smaller structural brain volume, and higher risk of dementia.MethodsOverall, 5985 participants in the Whitehall II study, aged 45–69 who had cardiac troponin I measured by a high-sensitivity assay at baseline (1997–99),… Continue reading High-sensitivity cardiac #troponin I and risk of #dementia: the 25-year longitudinal Whitehall II study
Best Evidence Summary of Traditional Chinese Medicine Nursing Technology for Patients With Chronic #Fatigue Syndrome
The existing guidelines and expert consensus on Traditional Chinese Medicine (#TCM) nursing technology for chronic fatigue syndrome (CFS) are few and not prominent. The relevant systematic reviews and randomized controlled trials lack scientific quality evaluation resulting in a lack of systematic and standardized evidence-based evidence of TCM nursing technology in clinical practice. Therefore, this study… Continue reading Best Evidence Summary of Traditional Chinese Medicine Nursing Technology for Patients With Chronic #Fatigue Syndrome
MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
INTRODUCTIONImpaired cerebrospinal fluid (CSF) dynamics may contribute to dementia, but human evidence is limited. We examined associations between magnetic resonance imaging–based proxies of CSF dynamics and incident dementia, and whether CSF dysfunction mediates links between cardiovascular risk and dementia.METHODSUsing the UK Biobank, we measured CSF dynamics: perivascular space (PVS) volume, diffusion tensor image analysis along… Continue reading MRI markers of #cerebrospinal fluid dynamics predict #dementia and mediate the impact of #cardiovascular risk
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