Hydroxychloroquine or chloroquine, often in combination with a second-generation macrolide, are being widely used for treatment of COVID-19, despite no conclusive evidence of their benefit. Although generally safe when used for approved indications such as autoimmune disease or malaria, the safety and benefit of these treatment regimens are poorly evaluated in COVID-19.. ..96 032 patients (mean… Continue reading #Hydroxychloroquine or #chloroquine with or without a macrolide for treatment of #COVID-19: a multinational registry analysis
Category: Infectivology
Reducing #antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper
Highlights •Global & national AMR actions focus on infection prevention in healthcare settings. •Home & everyday life settings contribute to acquiring & spreading AMR pathogens. •Targeted hygiene protects against infections, reducing antibiotic prescribing. • Targeted hygiene helps to minimize selection pressure for AMR development globally. •Reducing AMR requires greater focus on targeted hygiene in the… Continue reading Reducing #antibiotic prescribing and addressing the global problem of antibiotic resistance by targeted hygiene in the home and everyday life settings: A position paper
#Remdesivir for the Treatment of #Covid-19 — Preliminary Report
..We conducted a double-blind, randomized, placebo-controlled trial of intravenous remdesivir in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either remdesivir (200 mg loading dose on day 1, followed by 100 mg daily for up to 9 additional days) or placebo for up to 10 days.… Continue reading #Remdesivir for the Treatment of #Covid-19 — Preliminary Report
Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear.. ..Between 11 and 29 March 2020, 79 patients with IBD with COVID-19 were enrolled… Continue reading Outcomes of COVID-19 in 79 patients with #IBD in Italy: an IG-IBD study
Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
There are few primary care studies of the COVID-19 pandemic. We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network.. ..We identified 3802 SARS-CoV-2 test results, of which 587… Continue reading Risk factors for #SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study
ACUTE #KIDNEY INJURY IN PATIENTS HOSPITALIZED WITH #COVID-19
The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and April 5, 2020, at… Continue reading ACUTE #KIDNEY INJURY IN PATIENTS HOSPITALIZED WITH #COVID-19
High prevalence of Hepatitis C Infection among adult patients at four urban emergency departments
What is already known about this topic? Targeted testing for hepatitis C virus (HCV) infection in emergency departments (EDs) has been demonstrated to be a high-yield and effective intervention for identifying previously unrecognized infections, especially among persons born during 1945–1965. What is added by this report? Opt-out, universal HCV screening in EDs identified that nearly… Continue reading High prevalence of Hepatitis C Infection among adult patients at four urban emergency departments
A human monoclonal antibody blocking SARS-CoV-2 infection
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on… Continue reading A human monoclonal antibody blocking SARS-CoV-2 infection
The Possible Role of Vitamin #D in Suppressing Cytokine Storm and Associated Mortality in #COVID-19 Patients
Large-scale data show that the mortality of COVID-19 varies dramatically across populations, although the cause of these disparities is not well understood. In this study we investigated whether severe COVID-19 is linked to Vitamin D (Vit D) deficiency. Method Daily admission, recovery and deceased rate data for patients with COVID-19 from countries with a large… Continue reading The Possible Role of Vitamin #D in Suppressing Cytokine Storm and Associated Mortality in #COVID-19 Patients
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