Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection

Purpose: Data on the reliability of point-of-care (POC) tests for the rapid diagnosis of periprosthetic joint infections (PJI) using synovial fluid (SF) #D-dimer (DD), interleukin 6 (IL-6) and procalcitonin (PCT) are limited. This study aimed to address this issue by evaluating the diagnostic accuracy of POC tests for SF DD, IL-6 and PCT in comparison… Continue reading Synovial interleukin-6 point-of-care testing, alone and combined with D-dimer, supports rapid diagnosis of periprosthetic joint infection

Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration

Background: #D-dimer has gained considerable attention since its inclusion as a minor criterion in the 2018 International Consensus Meeting. However, evidence regarding its diagnostic accuracy for periprosthetic joint infection ( #PJI ) remains inconclusive. This systematic review and meta-analysis aimed to evaluate the diagnostic performance of D-dimer in diagnosing PJI and comprehensively explore the sources… Continue reading Revisiting D-dimer in periprosthetic joint infection: a comprehensive systematic review and meta-analysis with subgroup and heterogeneity exploration

Prognostic value of #D-dimer for adverse outcomes in patients with infective #endocarditis: an observational study

Increased D-dimer levels have been shown to correlate with adverse outcomes in various clinical conditions. However, few studies with a large sample size have been performed thus far to evaluate the prognostic value of D-dimer in patients with infective endocarditis (IE). Methods613 patients with IE were included in the study and categorized into two groups… Continue reading Prognostic value of #D-dimer for adverse outcomes in patients with infective #endocarditis: an observational study

Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability

Retrospective analyses suggest that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in patients with a low clinical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in patients with a moderate C-PTP ..We performed a prospective study in which pulmonary… Continue reading Diagnosis of Pulmonary #Embolism with d-#Dimer Adjusted to Clinical Probability