DICER is a key enzyme in microRNA (miRNA) biogenesis. Here we show that aerobic exercise training up-regulates DICER in adipose tissue of mice and humans. This can be mimicked by infusion of serum from exercised mice into sedentary mice and depends on AMPK-mediated signaling in both muscle and adipocytes. Adipocyte DICER is required for whole-body… Continue reading Dynamic changes in DICER levels in #adipose tissue control metabolic adaptations to #exercise
Tag: Metabolically-Healthy
Association of #Obesity Phenotypes with Electrocardiographic Markers of Poor Outcomes in the General Population
This study aimed to investigate the association of metabolically healthy obesity (MHO) and other obesity phenotypes with electrocardiographic (#ECG) markers to understand the pathophysiological basis of increased cardiovascular disease (CVD) risk associated with these phenotypes metabolically healthy without obesity [MHNO; reference] Higher odds of prolonged PR interval, P‐wave duration, and QRS duration were observed among… Continue reading Association of #Obesity Phenotypes with Electrocardiographic Markers of Poor Outcomes in the General Population
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